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First evidence of fetal DNA persisting in human brain tissue

Date:
September 26, 2012
Source:
Public Library of Science
Summary:
Small portions of male DNA, most likely left over in a mother's body by a male fetus can be detected in the maternal brain relatively frequently, according to a report published Sept. 26 in the open access journal PLOS ONE by William Chan of Fred Hutchinson Cancer Research Center and his colleagues.

Small portions of male DNA, most likely left over in a mother's body by a male fetus can be detected in the maternal brain relatively frequently, according to a report published Sep. 26 in the open access journal PLOS ONE by William Chan of Fred Hutchinson Cancer Research Center and his colleagues.

The process, called fetal 'microchimerism (Mc)', is common in other tissues such as blood, but this is the first evidence of male Mc in the human female brain. Microchimerism can be both beneficial and harmful to maternal health, since it is associated with processes such as tissue repair, as well as to autoimmune diseases.

Testing for the presence of a particular region of the Y-chromosome in autopsied brain tissues, the research team discovered that 63% of their samples showed potentially long-lasting Mc in multiple brain regions. They also found that women with Alzheimer's disease (AD) had less Mc than women without the disease.

According to the authors, this result warrants further investigation because previous reports have suggested that AD may be more prevalent in women with a higher number of pregnancies compared to childless women. The researchers commented that changes to the blood-brain barrier that occur during pregnancy could facilitate the process by which Mc is acquired into the human brain.

"This is the first evidence that microchimerism can cross the blood-brain barrier to establish male fetal tissue in the human female brain" says Chan.


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Public Library of Science. "First evidence of fetal DNA persisting in human brain tissue." ScienceDaily. ScienceDaily, 26 September 2012. <www.sciencedaily.com/releases/2012/09/120926213932.htm>.
Public Library of Science. (2012, September 26). First evidence of fetal DNA persisting in human brain tissue. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2012/09/120926213932.htm
Public Library of Science. "First evidence of fetal DNA persisting in human brain tissue." ScienceDaily. www.sciencedaily.com/releases/2012/09/120926213932.htm (accessed July 30, 2014).

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Male DNA Commonly Found in Women’s Brains, Likely from Prior Pregnancy With a Male Fetus

Sep. 26, 2012 Male DNA is commonly found in the brains of women, most likely derived from prior pregnancy with a male fetus, according to first-of-its-kind research conducted at Fred Hutchinson Cancer Research ... read more
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