Featured Research

from universities, journals, and other organizations

Low birth weight may increase risk for cardiovascular disease, kidney disease and diabetes

Date:
October 1, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
Being born underweight may have consequences other than the known short-term effects according to researchers. Low birth weight rats have an increased long-term risk for cardiovascular and kidney disease, and diabetes. Also, older females are at higher risk of developing high blood pressure before and during pregnancy, which may restrict growth in the womb, causing offspring to born at a low birth weight.

Being underweight at birth may have consequences above and beyond the known short-term effects says a research report published in the October 2012 issue of The FASEB Journal. The report shows that rats with a low birth weight have an increased long-term risk for developing cardiovascular disease, kidney disease, and diabetes. What's more, older females are at higher risk of developing high blood pressure before and during pregnancy, which in turn, may restrict growth in the womb, putting offspring at risk for being born at a low birth weight.

Related Articles


"Ensuring adequate growth of the baby in the womb will help to minimize the risk of cardiovascular diseases for babies when they become adults," said Mary E. Wlodek, Ph.D., a researcher involved in the work from the Department of Physiology at the University of Melbourne in Victoria, Australia. "Greater considerations regarding the effects of delayed child-bearing may also help to provide an optimal start to life."

To make this discovery, Wlodek and colleagues used female rats that were born small and compared them to rats of normal birth weight. These rats were aged to 12 months (middle to old age in rats) at which time they become pregnant. A number of measurements regarding health were performed on these female rats before and during pregnancy including blood pressure, kidney function and tests for diabetes. Researchers also compared these pregnant rats to a group of younger (4 month-old) pregnant rats to determine whether older rats have more difficult pregnancies that impact on the growth and development of their babies. Results showed that regardless of the mothers own birth weight, older mothers demonstrated a reduced ability to become pregnant. When they did become pregnant, they had altered blood sugar levels, poor pregnancy success and carried babies that were smaller or lighter in weight.

"This report offers more evidence that there's a Goldilocks zone for optimal human weight starting at birth," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "If you're too big, there are numerous studies suggesting an increased risk for long-term health problems. Now, we're seeing that if you're born too small, long-term health risks may also exist as well."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. A. Gallo, M. Tran, K. M. Moritz, A. J. Jefferies, M. E. Wlodek. Pregnancy in aged rats that were born small: cardiorenal and metabolic adaptations and second-generation fetal growth. The FASEB Journal, 2012; 26 (10): 4337 DOI: 10.1096/fj.12-210401

Cite This Page:

Federation of American Societies for Experimental Biology. "Low birth weight may increase risk for cardiovascular disease, kidney disease and diabetes." ScienceDaily. ScienceDaily, 1 October 2012. <www.sciencedaily.com/releases/2012/10/121001125413.htm>.
Federation of American Societies for Experimental Biology. (2012, October 1). Low birth weight may increase risk for cardiovascular disease, kidney disease and diabetes. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2012/10/121001125413.htm
Federation of American Societies for Experimental Biology. "Low birth weight may increase risk for cardiovascular disease, kidney disease and diabetes." ScienceDaily. www.sciencedaily.com/releases/2012/10/121001125413.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins