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Popular antidepressant might prevent heart failure

Date:
October 1, 2012
Source:
University of Michigan
Summary:
A medication usually used to help treat depression and anxiety disorders has the potential to help prevent heart failure, according to researchers.

A medication usually used to help treat depression and anxiety disorders has the potential to help prevent heart failure, according to researchers at the University of Michigan.

John Tesmer, research professor at the U-M Life Sciences Institute and professor in the Department of Pharmacology at the U-M Medical School, and his research team at the Tesmer lab found that paroxetine, a selective serotonin reuptake inhibitor (SSRI) sold under the name Paxil, inhibits G protein-coupled receptor kinase 2 (GRK2), a protein kinase that becomes over-expressed when people have heart failure.

Although so-called "off target" effects are known for many commonly used drugs, this is the first report that identifies a direct link between a specific SSRI and a protein target in the signal system they study, said Kristoff Homan, a postdoctoral fellow in Tesmer's lab.

The paper, "Paroxetine is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility," was published electronically ahead of print on Aug. 21 in ACS Chemical Biology.

The discovery almost did not happen. "It was completely serendipitous," Homan said.

Before beginning a larger search for compounds that would inhibit GRK2, the researchers screened a small library of approximately 2,000 compounds that contains many FDA-approved drugs as a test of their screening procedure -- and found that paroxetine binds to and inhibits the activity of GRK2.

GRK2 becomes increasingly expressed as the system that regulates normal heartbeat and the strength of the heart's contractions weakens. Paroxetine, the team found, improved the strength of the heart's contractions in an animal model without interfering with the heart rate.

Paroxetine is FDA-approved and has been clinically used as an SSRI for nearly 30 years, but at prescribed doses the compound probably does not inhibit GRK2 enough to be used for heart failure.

But if the researchers can identify modifications to the chemical structure of paroxetine that improve potency while decreasing SSRI activity, which Homan thinks they can do, the team hopes to start the process of optimization and to develop these compounds into therapeutic leads within the next several years, he said.


Story Source:

The above story is based on materials provided by University of Michigan. Note: Materials may be edited for content and length.


Journal Reference:

  1. David M. Thal, Kristoff T. Homan, Jun Chen, Emily K. Wu, Patricia M. Hinkle, Z. Maggie Huang, J. Kurt Chuprun, Jianliang Song, Erhe Gao, Joseph Y. Cheung, Larry A. Sklar, Walter J. Koch, John J.G. Tesmer. Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility. ACS Chemical Biology, 2012; 120821133243006 DOI: 10.1021/cb3003013

Cite This Page:

University of Michigan. "Popular antidepressant might prevent heart failure." ScienceDaily. ScienceDaily, 1 October 2012. <www.sciencedaily.com/releases/2012/10/121001141007.htm>.
University of Michigan. (2012, October 1). Popular antidepressant might prevent heart failure. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2012/10/121001141007.htm
University of Michigan. "Popular antidepressant might prevent heart failure." ScienceDaily. www.sciencedaily.com/releases/2012/10/121001141007.htm (accessed September 21, 2014).

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