Featured Research

from universities, journals, and other organizations

New hope for taming triple-negative breast cancer

Date:
October 2, 2012
Source:
University of Texas Health Science Center at San Antonio
Summary:
Researchers have identified molecules called microRNAS that can uniquely sensitize drug-resistant, triple-negative breast cancer to chemotherapy drugs. In preclinical studies, the team found microRNA effectively treated cancer in mice and was safe based on toxicity studies.

Disease-free survival is short-lived for women with triple-negative breast cancer -- a form of the disease that doesn't respond to hormone drugs and becomes resistant to chemotherapy. Thankfully, a promising line of study in the School of Medicine at The University of Texas Health Science Center San Antonio suggests it is possible to fine-tune the properties of this fearsome cancer, making it more sensitive to treatment.

Once preclinical studies have been completed in coming months, this new approach should be ready to test in female patients, a scientist said.

The research focuses on molecules called microRNAs that occur naturally throughout the body. These molecules play an important role during development and in disease processes. "Some microRNAs suppress cancer while others promote it," said Behyar Zoghi, M.D., Ph.D., hematology-medical oncology fellow in the School of Medicine and first author of a study presented at the recent American Society of Clinical Oncology (ASCO) meeting in San Francisco.

"We identified microRNAs that can uniquely sensitize drug-resistant, triple-negative breast cancer to chemotherapy drugs such as paclitaxel," said senior author Manjeet Rao, Ph.D., assistant professor of cellular and structural biology and a principal investigator at the Greehey Children's Cancer Research Institute of the UT Health Science Center. The institute's researchers pursue novel understandings about biology that will apply to both pediatric and adult cancers.

In preclinical studies, the team injected microRNA into mice with established tumors. "The microRNA not only killed the cancer and didn't let it come back, but was also safe based on toxicity studies of the liver and other tissues," Dr. Rao said.

The microRNA, delivered along with chemo, conditions the tumor so that it responds to a much lower dose of the drug and many side effects are prevented.

"MicroRNAs are very stable and small in size, so theoretically we don't need a very complex delivery vehicle," Dr. Rao said. "Importantly, the microRNAs that we studied can be very good prognostic markers, as they are detected in blood serum and expressed at significantly different levels in patients when compared with healthy individuals."

He expects the preclinical work to soon be translated to a first-in-humans Phase I clinical trial at the Cancer Therapy & Research Center (CTRC) at the UT Health Science Center San Antonio. The CTRC is one of four National Cancer Institute-designated Cancer Centers in Texas.

The team reported this study in September at the ASCO meeting. It was one of four studies selected for review by ASCO on the day it was presented. School of Medicine collaborators were Ismail Jatoi; M.D., Ph.D; Peter Ravdin, M.D., Ph.D.; Boyce Oliver Jr., M.D.; Anand Karnad, M.D.; Alfredo Santillan, M.D., M.P.H.; J. Saadi Imam, Ph.D.; Yao-Fu Chang, Ph.D.; Subbarayalu Panneerdoss, Ph.D.; and Suresh Prajapati, M.S. As part of his research, Dr. Zoghi was selected to receive a Texas Society of Clinical Oncology Fellows Award.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Cite This Page:

University of Texas Health Science Center at San Antonio. "New hope for taming triple-negative breast cancer." ScienceDaily. ScienceDaily, 2 October 2012. <www.sciencedaily.com/releases/2012/10/121002092843.htm>.
University of Texas Health Science Center at San Antonio. (2012, October 2). New hope for taming triple-negative breast cancer. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2012/10/121002092843.htm
University of Texas Health Science Center at San Antonio. "New hope for taming triple-negative breast cancer." ScienceDaily. www.sciencedaily.com/releases/2012/10/121002092843.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins