Featured Research

from universities, journals, and other organizations

Combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect: Study

Date:
October 9, 2012
Source:
Moffitt Cancer Center
Summary:
Researchers have discovered that combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect. The results, achieved by testing cancer cells in a laboratory, are surprising because chemotherapy generally reduces immunity and could cancel out the benefits of immunotherapy when given together.

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and Tianjin Medical University Cancer Institute and Hospital in China have discovered that combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect. The results, achieved by testing cancer cells in a laboratory, are surprising because chemotherapy generally reduces immunity and could cancel out the benefits of immunotherapy when given together.

Related Articles


Their study appears in the Aug. 31 online issue of Cancer Research, a publication of the American Association for Cancer Research.

"Our question of interest for this study was 'Can immunotherapy be used in combination with conventional chemotherapy in patients with advanced cancer?' " said study lead author Dmitry I. Gabrilovich, M.D., Ph.D., senior member of Moffitt's Immunology Program. "The use of conventional cancer chemotherapy in combination with immunotherapy was previously not thought to be appropriate due to the immunosuppresive effects usually associated with chemotherapy. However, we identified a mechanism by which the two therapies could work together."

The mechanism involved was the dramatic upregulation of the mannose-6-phosphate receptor (MPR) to the tumor cell surface. According to the researchers, normally more than 90 percent of total MPR is localized inside the cells, but after chemotherapy, large amounts of MPR localized on the cell membrane.

The researchers attributed this to autophagy.

"Autophagy is a reversible process than can contribute to both tumor cell death and survival," explained Gabrilovich. "When this pathway is initiated, cellular material is sequestered by autophagosome. The mechanism of autophagosome formation depends on the type of chemotherapy used."

According to the authors, the MPR upregulation effect was seen in every tumor model they tested and with all drugs they used. However, the effect of the combined treatment was seen only when chemotherapy was given within a specific window of time during which levels of MPR were observed on tumor cells. Much more about the mechanism needs to be clarified, researchers said.

"The relationship between autophagy and tumor immunity requires further investigation," Gabrilovich said. "Our study represents a novel concept relating to the interaction between cytotoxic T cells and tumor cells undergoing autophagy. We are suggesting that this process could be exploited during chemotherapy or radiation therapy, as well as with other treatments that cause autophagy of cells, although treatments need to be carefully timed."

The authors concluded that their data demonstrated that combining chemotherapy and immunotherapy for patients with advanced cancer has "a strong rationale."

Moffitt research scientist Rupal Ramakrishnan, Ph.D., was a first author and major contributor to this study. The work was supported in part by a grant from Donald A. Adam Comprehensive Melanoma Research Center of Excellence, National Institutes of Health grant R01CA103921 and by the analytic microscopy and flow cytometry cores at Moffitt.


Story Source:

The above story is based on materials provided by Moffitt Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Ramakrishnan, C. huang, H.-I. Cho, M. Lloyd, J. Johnson, X. Ren, S. Altiok, D. Sullivan, J. Weber, E. Celis, D. I. Gabrilovich. Autophagy induced by conventional chemotherapy mediates tumor cell sensitivity to immunotherapy. Cancer Research, 2012; DOI: 10.1158/0008-5472.CAN-12-2236

Cite This Page:

Moffitt Cancer Center. "Combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect: Study." ScienceDaily. ScienceDaily, 9 October 2012. <www.sciencedaily.com/releases/2012/10/121009101339.htm>.
Moffitt Cancer Center. (2012, October 9). Combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect: Study. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2012/10/121009101339.htm
Moffitt Cancer Center. "Combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect: Study." ScienceDaily. www.sciencedaily.com/releases/2012/10/121009101339.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins