Featured Research

from universities, journals, and other organizations

Combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect: Study

Date:
October 9, 2012
Source:
Moffitt Cancer Center
Summary:
Researchers have discovered that combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect. The results, achieved by testing cancer cells in a laboratory, are surprising because chemotherapy generally reduces immunity and could cancel out the benefits of immunotherapy when given together.

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and Tianjin Medical University Cancer Institute and Hospital in China have discovered that combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect. The results, achieved by testing cancer cells in a laboratory, are surprising because chemotherapy generally reduces immunity and could cancel out the benefits of immunotherapy when given together.

Their study appears in the Aug. 31 online issue of Cancer Research, a publication of the American Association for Cancer Research.

"Our question of interest for this study was 'Can immunotherapy be used in combination with conventional chemotherapy in patients with advanced cancer?' " said study lead author Dmitry I. Gabrilovich, M.D., Ph.D., senior member of Moffitt's Immunology Program. "The use of conventional cancer chemotherapy in combination with immunotherapy was previously not thought to be appropriate due to the immunosuppresive effects usually associated with chemotherapy. However, we identified a mechanism by which the two therapies could work together."

The mechanism involved was the dramatic upregulation of the mannose-6-phosphate receptor (MPR) to the tumor cell surface. According to the researchers, normally more than 90 percent of total MPR is localized inside the cells, but after chemotherapy, large amounts of MPR localized on the cell membrane.

The researchers attributed this to autophagy.

"Autophagy is a reversible process than can contribute to both tumor cell death and survival," explained Gabrilovich. "When this pathway is initiated, cellular material is sequestered by autophagosome. The mechanism of autophagosome formation depends on the type of chemotherapy used."

According to the authors, the MPR upregulation effect was seen in every tumor model they tested and with all drugs they used. However, the effect of the combined treatment was seen only when chemotherapy was given within a specific window of time during which levels of MPR were observed on tumor cells. Much more about the mechanism needs to be clarified, researchers said.

"The relationship between autophagy and tumor immunity requires further investigation," Gabrilovich said. "Our study represents a novel concept relating to the interaction between cytotoxic T cells and tumor cells undergoing autophagy. We are suggesting that this process could be exploited during chemotherapy or radiation therapy, as well as with other treatments that cause autophagy of cells, although treatments need to be carefully timed."

The authors concluded that their data demonstrated that combining chemotherapy and immunotherapy for patients with advanced cancer has "a strong rationale."

Moffitt research scientist Rupal Ramakrishnan, Ph.D., was a first author and major contributor to this study. The work was supported in part by a grant from Donald A. Adam Comprehensive Melanoma Research Center of Excellence, National Institutes of Health grant R01CA103921 and by the analytic microscopy and flow cytometry cores at Moffitt.


Story Source:

The above story is based on materials provided by Moffitt Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Ramakrishnan, C. huang, H.-I. Cho, M. Lloyd, J. Johnson, X. Ren, S. Altiok, D. Sullivan, J. Weber, E. Celis, D. I. Gabrilovich. Autophagy induced by conventional chemotherapy mediates tumor cell sensitivity to immunotherapy. Cancer Research, 2012; DOI: 10.1158/0008-5472.CAN-12-2236

Cite This Page:

Moffitt Cancer Center. "Combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect: Study." ScienceDaily. ScienceDaily, 9 October 2012. <www.sciencedaily.com/releases/2012/10/121009101339.htm>.
Moffitt Cancer Center. (2012, October 9). Combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect: Study. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2012/10/121009101339.htm
Moffitt Cancer Center. "Combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect: Study." ScienceDaily. www.sciencedaily.com/releases/2012/10/121009101339.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins