Featured Research

from universities, journals, and other organizations

DNA method can provide more effective treatment of childhood cancer

Date:
October 15, 2012
Source:
University of Gothenburg
Summary:
After leukemia and brain tumors, neuroblastoma is the most common form of cancer to affect children. Researchers have now studied a DNA method which is now used for all cases of neuroblastoma in Sweden, and which has led to more effective treatment at individual level.

After leukaemia and brain tumours, neuroblastoma is the most common form of cancer to affect children. A thesis from the Sahlgrenska Academy, University of Gothenburg, Sweden, has studied a DNA method which is now used for all cases of neuroblastoma in Sweden, and which has led to more effective treatment at individual level.

Related Articles


Neuroblastoma affects around 20 children each year, most of them under the age of two. This form of cancer, which affects the peripheral nervous system, is particularly unusual: some tumours can regress spontaneously without treatment, while others are highly aggressive and have a poor prognosis despite intensive treatment.

Researchers at the Sahlgrenska Academy, University of Gothenburg have shown that DNA analyses can be used to differentiate the subgroups of this type of cancer, which it is hoped could lead to a more personalized treatment.

"The ultimate scenario would be first to analyze the tumour, and then to introduce medicine that targets the specific properties of that particular tumour," explains Hanna Kryh, who presents the results in her thesis. "In this way, the treatment could be personalized so that patients with a more aggressive form would receive an intensive treatment, while patients with a less aggressive form could be spared unnecessary side-effects. Our studies are a real first step towards such a form of personalized treatment strategy."

The method is already used for all new cases of neuroblastoma in Sweden, in order to make a sounder diagnosis and to place the patient in the appropriate treatment group.

"We have also identified a previously unknown subgroup of neuroblastoma, with a DNA profile that helps us to investigate which genes are important in terms of tumour development, and may be suitable targets for future treatment."

The researchers hope that the DNA method will be used as a starting point for the development of patient-specific tests that can detect tumour cells in blood or bone marrow samples.

"This would allow us to monitor how well the patient is responding to the treatment, and to detect remaining tumour cells, that could result in a relapse, at an early stage."

The thesis "Molecular characterization of neuroblastoma tumours -- A basis for personalized medicine" was defended in June.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Cite This Page:

University of Gothenburg. "DNA method can provide more effective treatment of childhood cancer." ScienceDaily. ScienceDaily, 15 October 2012. <www.sciencedaily.com/releases/2012/10/121015093702.htm>.
University of Gothenburg. (2012, October 15). DNA method can provide more effective treatment of childhood cancer. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2012/10/121015093702.htm
University of Gothenburg. "DNA method can provide more effective treatment of childhood cancer." ScienceDaily. www.sciencedaily.com/releases/2012/10/121015093702.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins