Featured Research

from universities, journals, and other organizations

Intermittent binge drinking could cause significant brain impairment within months, study suggests

Date:
October 15, 2012
Source:
Scripps Research Institute
Summary:
A study of binge-drinking rodents suggests that knocking back a few drinks every few days may swiftly reduce one's capacity to control alcohol intake. Scientists found signs of cognitive impairment in rats similar to that seen in established alcoholism after the animals had only a few months of intermittent access to alcohol. Remarkably, these impairments did not appear at all in rats with 24/7 access to alcohol, whose alcohol intake remained stable.

A study of binge-drinking rodents suggests that knocking back a few drinks every few days may swiftly reduce one's capacity to control alcohol intake. Scientists at The Scripps Research Institute (TSRI) found signs of cognitive impairment in rats similar to that seen in established alcoholism after the animals had only a few months of intermittent access to alcohol.

Related Articles


The researchers linked the rats' impairment to a small group of neurons that inhibit "executive control" functions in the prefrontal cortex of the brain. These neurons were unusually active in the periods between drinking binges -- and the more active they were, the more the rats drank when they next had access to alcohol. The finding, if confirmed in studies of humans, could lead to better treatments, preventive approaches and diagnostic tests for problem drinking and possibly other addiction-like behaviors.

"We suspect that this very early adaptation of the brain to intermittent alcohol use helps drive the transition from ordinary social drinking to binge drinking and dependence," said Olivier George, PhD, senior staff scientist at TSRI and lead author of the study.

"This research is giving us a window into the early development of the addiction process," said the study's senior author, George F. Koob, PhD, chairman of the Committee on the Neurobiology of Addictive Disorders and co-director of the Pearson Center for Alcoholism and Addiction Research at TSRI.

The new study appears online ahead of print in the Early Edition of the Proceedings of the National Academy of Sciences the week of October 15, 2012.

Binge Drinking Versus Consuming a Little Every Day

Scientists have long known that alcohol dependence and other addictions feature striking changes in the brain. These include an overactivity of stress-related circuits and a weakening of the prefrontal executive control circuits that normally act as a brake on emotional reactions and impulsive behaviors. What hasn't been understood is the sequence of neural events by which these changes come about.

To find out more about these early events, Dr. George set up a study of rats that had access to alcohol only three days per week (Tuesday, Thursday and Saturday). Previous research had shown that rats in this intermittent-access situation start out as modest drinkers, but eventually turn into binge drinkers, consuming even more than rats that have 24/7 access to alcohol. "It's like a lot of things in life that the brain perceives as good -- if it loses access to it, you feel bad, you get into a negative emotional state, say a little bit frustrated, and so you take more the next time you have access," said Dr. George.

The team confirmed that the group of rats with intermittent access drank markedly more alcohol, on average, than those with continuous access after only six weeks. In tests conducted a few weeks later, during "dry" intervals between drinking bouts, the binge drinking rats scored poorly on measures of working memory, an essential element of executive control. Tests of their brain tissue also revealed that during these withdrawal periods -- when the animals would have been expected to be craving alcohol -- the prefrontal cortex seemed relatively disconnected from the structures it is meant to regulate, such as the emotion-related amygdala.

"We normally see such changes in the brains of humans or other animals that are highly dependent on alcohol, but here we found these changes in the rats after only a few months of intermittent alcohol use," said Dr. George.

Remarkably, these impairments did not appear at all in the drink-every-day rats, whose alcohol intake remained stable. "They just drink a bit like the French way, the equivalent of a couple of glasses of wine every day, and they're fine," said Dr. George. "They don't escalate."

As for the binge-drinking rats, their cognitive impairment went away if they were kept off alcohol for about two weeks -- but the impairment would return if they simply drank again. "One can see the vicious cycle here," said Dr. George. "They drink to restore normal prefrontal function, but ultimately that leads to even greater impairment."

"This process would be of particular concern in adolescents and young adults, in whom the prefrontal cortex isn't even fully developed," Dr. Koob said.

Changes in the Brain

Further tests suggested that the immediate cause of the impairment in the binge-drinking rats was a small population of medial prefrontal cortex neurons known as GABA interneurons. These neurons are known to serve as "dimmer switches" for nearby excitatory neurons within the medial prefrontal cortex. In the binge-drinking rats, the GABA neurons were unusually active during periods of impairment. In general, the more active these GABA neurons are, the less the prefrontal cortex is able to do its primary job of exerting executive control over other, relatively impulse-driven brain regions.

The team also found hints that the GABA interneurons in the binge-drinking rats may be activated by adjacent prefrontal neurons that secrete the stress neurotransmitter CRF. This molecule is already closely associated with alcoholism. In alcohol-dependent rats, and likely in human alcoholics too, abstinence triggers a flood of CRF in the central nucleus of the amygdala -- creating a feeling of anxiety that typically can only be alleviated by drinking again. "Now we see that that this early dysregulation of the prefrontal cortex by binge drinking may also be driven by CRF," Dr. Koob said.

The Koob lab and other teams of addiction researchers have begun to investigate CRF-blocking drugs as potential treatments for established alcohol dependence. The new results, Dr. Koob said, raise the possibility that such drugs might also work to prevent alcohol dependence. CRF may turn out to be a good target for diagnostic tests, too. "When someone develops a molecule that binds to CRF with high enough specificity, so that we can measure CRF activity in the living human brain with a PET scan, we might then have a good way to detect if someone is alcohol-dependent or on the path to dependency," he said.

In addition to Drs. Koob and George, the other contributors to the study, "Alcohol withdrawal activates GABA and corticotropin releasing factor (CRF) neurons in the medial prefrontal cortex (mPFC) that predict cognitive impairment and escalation of alcohol intake," are Chelsea Sanders, John Freiling, Edward Grigoryan, Shayla Vu, Camryn D. Allen, Elena Crawford, and Chitra D. Mandyam, all from TSRI.

The research was supported by grants from the National Institutes of Health (AA006420, AA008459, AA020608) and the Pearson Center for Alcoholism and Addiction Research at TSRI.


Story Source:

The above story is based on materials provided by Scripps Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Olivier George, Chelsea Sanders, John Freiling, Edward Grigoryan, Shayla Vu, Camryn D. Allen, Elena Crawford, Chitra D. Mandyam, and George F. Koob. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1116523109

Cite This Page:

Scripps Research Institute. "Intermittent binge drinking could cause significant brain impairment within months, study suggests." ScienceDaily. ScienceDaily, 15 October 2012. <www.sciencedaily.com/releases/2012/10/121015152009.htm>.
Scripps Research Institute. (2012, October 15). Intermittent binge drinking could cause significant brain impairment within months, study suggests. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2012/10/121015152009.htm
Scripps Research Institute. "Intermittent binge drinking could cause significant brain impairment within months, study suggests." ScienceDaily. www.sciencedaily.com/releases/2012/10/121015152009.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com
1st Responders Trained for Autism Sensitivity

1st Responders Trained for Autism Sensitivity

AP (Dec. 16, 2014) More departments are ordering their first responders to sit in on training sessions that focus on how to more effectively interact with those with autism spectrum disorder (Dec. 16) Video provided by AP
Powered by NewsLook.com
Guys Are Idiots, According To Sarcastic Study

Guys Are Idiots, According To Sarcastic Study

Newsy (Dec. 12, 2014) A study out of Britain suggest men are more idiotic than women based on the rate of accidental deaths and other factors. Video provided by Newsy
Powered by NewsLook.com
Believing in Father Christmas Good for Children's Imaginations

Believing in Father Christmas Good for Children's Imaginations

AFP (Dec. 12, 2014) As the countdown to Christmas gets underway, so too does the Father Christmas conspiracy. But psychologists say that telling our children about Santa, flying reindeer and elves is good for their imaginations. Duration: 01:57 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins