Featured Research

from universities, journals, and other organizations

Compounds that could thwart post-traumatic stress disorder identified

Date:
October 15, 2012
Source:
Indiana University
Summary:
A brain pathway that is stimulated by traumatic or fearful experiences can be disrupted by two compounds that show promise for preventing post-traumatic stress disorder, researchers have reported.

A brain pathway that is stimulated by traumatic or fearful experiences can be disrupted by two compounds that show promise for preventing post-traumatic stress disorder, Indiana University researchers reported.

Related Articles


In a presentation prepared for the Neuroscience 2012 scientific conference in New Orleans Oct. 13 to 17, Anantha Shekhar and colleagues from IU reported the results of experiments with rats using a standard methodology called a conditioned fear test.

The neural signaling activated by fearful experiences -- a process that also is involved in learning and in memory formation -- begins when the neurotransmitter glutamate activates a receptor called NMDA, resulting in a later protein reaction involving production of nitrous oxide, another chemical messenger in the brain.

The two small molecules tested, known as IC87201 and ZL006, are known to disrupt such nitrous oxide production.

In the experiment, rats treated with either of the two compounds showed significantly less fear response than the untreated rats, the researchers reported.

The results, the researchers said, supported their hypothesis that the NMDA-mediated nitrous oxide production is important in successful formation of fear memories, and disrupting that interaction could potentially offer a means of preventing long-term post-traumatic stress disorder symptoms

Repeated intense activation of the brain network for fear makes it vulnerable to developing hypersensitivity, said Shekhar, Raymond E. Houk Professor of Psychiatry and director of the Indiana Clinical and Translational Sciences Institute.

"The majority of people who have a traumatic event, perhaps about 80 percent, will have some post-traumatic stress disorder symptoms for a few days. Only about 20 percent will have long-term problems, but currently there is no way to predict who those people will be," Shekhar said.

With that uncertainty, it would be appropriate to administer the treatment to all traumatized patients within a few hours of the incident, such as when a person arrives at an emergency room after an accident or a field hospital after a military incident, he said.

The next steps would be to optimize compounds and begin drug development efforts, Shekhar said.

Shekhar will discuss "Post-trauma disruption of nNOS-PSD95 protein-protein interaction is an effective means to ameliorate conditioned fear," on October 15.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Cite This Page:

Indiana University. "Compounds that could thwart post-traumatic stress disorder identified." ScienceDaily. ScienceDaily, 15 October 2012. <www.sciencedaily.com/releases/2012/10/121015162413.htm>.
Indiana University. (2012, October 15). Compounds that could thwart post-traumatic stress disorder identified. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2012/10/121015162413.htm
Indiana University. "Compounds that could thwart post-traumatic stress disorder identified." ScienceDaily. www.sciencedaily.com/releases/2012/10/121015162413.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Marijuana Nowhere Near As Deadly As Alcohol: Study

Marijuana Nowhere Near As Deadly As Alcohol: Study

Newsy (Feb. 25, 2015) A new study says marijuana is about 114 times less deadly than alcohol. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins