Featured Research

from universities, journals, and other organizations

Gene that's usually bad news loses its punch if you live to your 90s

Date:
October 25, 2012
Source:
Mayo Clinic
Summary:
A gene linked to the risk of developing Alzheimer's, heart disease and diabetes becomes less important to quality of life once people hit their 90s, a new study shows. At that point, good friends and a positive attitude have a bigger impact, the researchers say.

A gene linked to the risk of developing Alzheimer's, heart disease and diabetes becomes less important to quality of life once people hit their 90s, a Mayo Clinic study shows. At that point, good friends and a positive attitude have a bigger impact, the researchers say.

The findings are published this month in the Journal of American Medical Directors Association.

Researchers used the National Institutes of Health-supported Rochester Epidemiology Project, a database of patient records in Olmsted County, Minn., to find people ages 90 to 99 living on their own or in long-term care. The 121 participants completed an interview, a physical exam and a quality-of-life questionnaire. Participants were divided into groups based on their cognitive function, to sort out the effects of age and disease on well-being, and blood samples were taken for genotyping.

Researchers discovered that those who carried the gene in question, known as ApoE4, were no worse off than others in the study.

"We found if people had good physical, intellectual, and emotional well-being, more social connectedness, and if they perceived themselves to have better coping skills, they felt they had better quality of life," says co-author Maria Lapid, M.D., a Mayo Clinic psychiatrist.

"The study shows that the ApoE4 genotype doesn't determine what your quality of life will be, and that, regardless of your gender, environmental factors play a significant role in your physical, emotional, spiritual, and social well-being," she says. "You can have good quality of life regardless of this gene."

The median age of those studied was 93; 87 percent were women. Those reporting poorer quality of life tended to be men, for reasons that are unclear, and people who experienced pain.

The Alzheimer's Association, National Institute on Aging, and Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program of the Mayo Foundation funded the study.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ajay K. Parsaik, Maria I. Lapid, Teresa A. Rummans, Ruth H. Cha, Bradley F. Boeve, Vernon (Shane) S. Pankratz, Eric G. Tangalos, Ronald C. Petersen. ApoE and Quality of Life in Nonagenarians. Journal of the American Medical Directors Association, 2012; 13 (8): 704 DOI: 10.1016/j.jamda.2012.06.012

Cite This Page:

Mayo Clinic. "Gene that's usually bad news loses its punch if you live to your 90s." ScienceDaily. ScienceDaily, 25 October 2012. <www.sciencedaily.com/releases/2012/10/121025105739.htm>.
Mayo Clinic. (2012, October 25). Gene that's usually bad news loses its punch if you live to your 90s. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2012/10/121025105739.htm
Mayo Clinic. "Gene that's usually bad news loses its punch if you live to your 90s." ScienceDaily. www.sciencedaily.com/releases/2012/10/121025105739.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins