Featured Research

from universities, journals, and other organizations

Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy

Date:
December 5, 2012
Source:
Mayo Clinic
Summary:
A new study shows that a less invasive procedure known as sentinel lymph node surgery successfully identified whether cancer remained in lymph nodes in 91 percent of patients with node-positive breast cancer who received chemotherapy before their surgery.

Most patients whose breast cancer has spread to their lymph nodes have most of the lymph nodes in their armpit area removed after chemotherapy to see if any cancer remains. A study conducted through the American College of Surgeons Oncology Group and led by Judy Boughey, M.D. a breast surgeon at Mayo Clinic shows that a less invasive procedure known as sentinel lymph node surgery successfully identified whether cancer remained in lymph nodes in 91 percent of patients with node-positive breast cancer who received chemotherapy before their surgery. In sentinel lymph node surgery, only a few lymph nodes, the ones most likely to contain cancer, are removed.

The findings are being presented at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium.

"Since treatment with chemotherapy before surgery can eliminate cancer in the lymph nodes in some patients, we were interested in evaluating whether sentinel lymph node surgery could successfully identify whether cancer remained in the lymph nodes after chemotherapy," says Dr. Boughey. Removing only a few lymph nodes reduces the risk of surgical complications such as numbness and arm swelling, she says.

Researchers studied 756 women with node-positive breast cancer who received chemotherapy as an initial treatment. Of study participants, 637 patients had both sentinel lymph node and axillary lymph node surgery. Sentinel lymph node surgery correctly identified whether cancer lingered in 91 percent of patients, including 255 patients with node-negative breast cancer and 326 patients with continuing node-positive disease.

Researchers also found that 40 percent of the patients had complete eradication of the cancer from the lymph nodes. The study had a false-negative rate of 12.6 percent and the false negative rate was significantly lower with the use of dual tracers (blue dye and radiolabeled colloid) to identify the sentinel lymph nodes.

Dr. Boughey says that technical factors in surgery are important to help ensure correct staging, the process of determining how far cancer may have spread.

The study was conducted through the American College of Surgeons Oncology Group and funded by the National Cancer Institute.

Other authors include: Vera Suman, Ph.D., Mayo Clinic, Rochester; Elizabeth Mittendorf, M.D., MD Anderson Cancer Center; Gretchen Ahrendt, M.D., Magee-Women's Surgical Associates; Lee Wilke, M.D., University of Wisconsin, Madison; Bret Taback, M.D., Columbia University Medical Center; M. Leitch, M.D., University of Texas Southwestern Medical Center, Dallas; Teresa Flippo-Morton, M.D., Carolina's Medical Center, Charlotte; David Byrd, M.D., University of Washington Medical Center, Seattle; David Ollila, M.D., University of North Carolina- Chapel Hill; Thomas Julian, M.D., Allegheny General Hospital, Pittsburgh; Sarah McLaughlin, M.D., Mayo Clinic, Jacksonville; Linda McCall, Duke University Medical Center; W. Symmans, M.D., MD Anderson Cancer Center; Huong Le-Petross, M.D., MD Anderson Cancer Center; Bruce Haffty, M.D., The Cancer Institute of New Jersey; Thomas Buchholz, M.D., MD Anderson Cancer Center, Kelly Hunt, M.D., M.D. Anderson Cancer Center.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy." ScienceDaily. ScienceDaily, 5 December 2012. <www.sciencedaily.com/releases/2012/12/121205102611.htm>.
Mayo Clinic. (2012, December 5). Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2012/12/121205102611.htm
Mayo Clinic. "Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy." ScienceDaily. www.sciencedaily.com/releases/2012/12/121205102611.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins