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Reproduction and life span are intertwined

Date:
December 17, 2012
Source:
The Max Planck Institute for Biology of Ageing/ Max-Planck-Institut für Biologie des Alterns
Summary:
Removing a roundworm's germ cells prolongs the animal's life. The gonad is well known to be important for reproduction but also affects animal life span. Removal of germ cells – the sperm and egg producing cells – increases longevity of the roundworm Caenorhabditis elegans. However, the underlying molecular mechanisms were a mystery. Now scientists have discovered that germ cell removal flips a “molecular switch” that extends the life span by using components of a “developmental clock”.

The gonad is well known to be important for reproduction but also affects animal life span. Removal of germ cells - the sperm and egg producing cells - increases longevity of the roundworm Caenorhabditis elegans. However, the underlying molecular mechanisms were a mystery. Now scientists at the Cologne-based Max Planck Institute for Biology of Ageing, have discovered that germ cell removal flips a "molecular switch" that extends the life span by using components of a "developmental clock."

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The roundworm Caenorhabditis elegans is a commonly used model organism in the field of aging research. It develops from an egg to adult through four larval stages. These developmental stages are controlled by a developmental clock. Yidong Shen and colleagues working in the department of Director Adam Antebi used a laser to remove the germ cells.

They found that the remaining gonadal cells trigger production of a steroid hormone called dafachronic acid. Dafachronic acid activates so-called microRNAs, which work as tiny molecular switches causing changes in gene expression that promote longevity. Interestingly, this same steroid hormone-microRNA switch was previously shown by Antebi and colleagues to be part of the developmental clock. Thus, the loss of the germ cells ultimately causes the worm to use developmental timers to put in motion a life-prolonging programme.

In uncovering these findings, the Max Planck scientists have added some more pieces to the puzzle of describing and understanding how longevity is regulated. The question now is whether humans also possess a similar microRNA-controlled switch system.


Story Source:

The above story is based on materials provided by The Max Planck Institute for Biology of Ageing/ Max-Planck-Institut für Biologie des Alterns. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y. Shen, J. Wollam, D. Magner, O. Karalay, A. Antebi. A Steroid Receptor-MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad. Science, 2012; 338 (6113): 1472 DOI: 10.1126/science.1228967

Cite This Page:

The Max Planck Institute for Biology of Ageing/ Max-Planck-Institut für Biologie des Alterns. "Reproduction and life span are intertwined." ScienceDaily. ScienceDaily, 17 December 2012. <www.sciencedaily.com/releases/2012/12/121217091157.htm>.
The Max Planck Institute for Biology of Ageing/ Max-Planck-Institut für Biologie des Alterns. (2012, December 17). Reproduction and life span are intertwined. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2012/12/121217091157.htm
The Max Planck Institute for Biology of Ageing/ Max-Planck-Institut für Biologie des Alterns. "Reproduction and life span are intertwined." ScienceDaily. www.sciencedaily.com/releases/2012/12/121217091157.htm (accessed April 18, 2015).

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