Featured Research

from universities, journals, and other organizations

Nanomechanical signature of breast cancer

Date:
February 1, 2013
Source:
Biophysical Society
Summary:
Differences in the stiffness of cancerous versus healthy tissue may aid in diagnosis and therapy, researchers say.

The texture of breast cancer tissue differs from that of healthy tissue. Using a cutting-edge tissue diagnostic device, a group of researchers in Basel, Switzerland, has determined one key difference: cancerous tissue is a mix of stiff and soft zones, whereas healthy tissue has uniform stiffness. This new finding may one day help improve breast cancer diagnosis and therapy by providing a unique nanomechanical signature of tumor tissue properties that indicates the potential for the cancer to spread.

The team will present its work at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.

"It is slowly being recognized that a key to the cancer problem lies in the physical properties of the tumor tissue and that biomechanics plays a key role in cancer cell migration, invasion, and metastasis," explains Marija Plodinec of the University of Basel in Switzerland. However, contradictory opinions persist about tissue texture, and the information is hard to get at -- cellular mechanics happen at the nanoscale, 1-100 millionths of a meter. This research may help resolve the controversy.

To determine stiffness, the team applied a nanoscale microscope tip to a breast tissue biopsy to make an indentation, then visualized and measured the indentation with an indentation-type atomic force microscope, which provides unprecedented spatial resolution. "The most significant outcome of our measurements is determining that in healthy tissue the stiffness of the sample is homogeneous," Plodinec says. "Benign tissue exhibits a larger variability and malignant tissue shows a unique, very heterogeneous profile with soft and stiff parts alternating."

A key aspect of their experiment is the adaptation of atomic force microscopy to rapidly collect and correlate nanoscale stiffness measurements across entire biopsy samples. They used a device called ARTIDIS ("Automated and Reliable Tissue Diagnostics"), invented by Plodinec and colleagues Marko Loparic and Roderick Lim. Partnering with industry, their next step is to develop ARTIDIS into an easy-to-use device for clinical application, hopefully within two years.

"A critical advantage of ARTIDIS technology, as we see it, is that it provides an estimate of tumor aggressiveness and metastatic spread based on the unique nanomechanical signature," Plodinec says. "This signature may have potential prognostic and predictive value as a marker for therapeutic applications."


Story Source:

The above story is based on materials provided by Biophysical Society. Note: Materials may be edited for content and length.


Cite This Page:

Biophysical Society. "Nanomechanical signature of breast cancer." ScienceDaily. ScienceDaily, 1 February 2013. <www.sciencedaily.com/releases/2013/02/130201095938.htm>.
Biophysical Society. (2013, February 1). Nanomechanical signature of breast cancer. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2013/02/130201095938.htm
Biophysical Society. "Nanomechanical signature of breast cancer." ScienceDaily. www.sciencedaily.com/releases/2013/02/130201095938.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins