Featured Research

from universities, journals, and other organizations

New more effective treatment option for breast cancer patients approved by FDA

Date:
February 22, 2013
Source:
Rush University Medical Center
Summary:
Patients with HER2-positive breast cancer, a particularly aggressive form of breast cancer, now have a new, effective and less toxic therapeutic option. On Feb., 22, the U.S. Food and Drug Administration (FDA) approved the new treatment drug, Kadcyla (trastuzumab emtansine), also known as TDM-1, which combines Traztuzumab, also called Herceptin, with the powerful chemotherapy drug emtansine.

Patients with HER2-positive breast cancer, a particularly aggressive form of breast cancer, now have a new, effective and less toxic therapeutic option.

Related Articles


On Friday, Feb., 22, the Food and Drug Administration (FDA) approved the new treatment drug, Kadcyla (trastuzumab emtansine), also known as TDM-1, which combines Traztuzumab, also called Herceptin, with the powerful chemotherapy drug emtansine.

The drug therapy is developed by Roche-owned Genentech, which funded the study.

Results from clinical trials of the drug TDM-1, known as "Super Herceptin," showed that it was more effective and less toxic than the standard regimen for this type of tumor. The medication kept patients free of disease for longer than the standard chemotherapy regimen.

Rush was one of only two medical centers in Illinois and a small number across the country studying the treatment.

HER-2 positive breast cancer patients have been found to be positive for carrying a protein that promotes the growth of cancer cells. TDM-1 is taken directly to cells that have the HER2 protein on the membrane, such as the cancer cells, while sparing normal cells. This results in less toxicity from the chemotherapy drug.

"TDM-1 works like the original drug Herceptin by hunting down and interfering with the cancer cells," said Dr. Melody Cobleigh, Director of the Comprehensive Breast Center at Rush and lead investigator of the TDM-1 clinical trials at Rush. "But this newer version, called TDM-1, is Herceptin with a chemotherapy drug attached. The combination delivers a one-two punch, seeking out the cancer cells and not only stopping growth but delivering the chemo right to the cell."

"The tumor cell basically eats the TDM-1 and then, the TDM-1 gets released and destroys the tumor cell from the inside out," said Cobleigh.

"The best part for patients is that it is very tolerable and does not have the debilitating side effects characteristic of other cancer drugs," said Cobleigh.

With TDM-1, patients did not even lose their hair and experienced far fewer other side effects.

"This really can have an impact on patient's lives," said Cobleigh.

About 1,000 patients with HER-2 positive breast cancer were enrolled in the Phase III, randomized, multicenter, trial of TDM-1. One group of patients received TDM-1 and the other group received two standard chemotherapy drugs. The TDM-1 patients remained cancer-free for 9.6 months -- progression-free survival -- while the standard treatment group was cancer-free for 6.4 months. Progression-free survival is the time that elapses between the start of a treatment and the time the cancer gets worse.

"This therapy has shown to be effective when other standards treatments have stopped working," said Cobleigh. "For men and women, the treatment gave them the opportunity to lead normal lives."

For more information about the drug therapy being offered at Rush, please contact the Rush Comprehensive Breast Cancer Center at (312) 563-2325.


Story Source:

The above story is based on materials provided by Rush University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Rush University Medical Center. "New more effective treatment option for breast cancer patients approved by FDA." ScienceDaily. ScienceDaily, 22 February 2013. <www.sciencedaily.com/releases/2013/02/130222120705.htm>.
Rush University Medical Center. (2013, February 22). New more effective treatment option for breast cancer patients approved by FDA. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2013/02/130222120705.htm
Rush University Medical Center. "New more effective treatment option for breast cancer patients approved by FDA." ScienceDaily. www.sciencedaily.com/releases/2013/02/130222120705.htm (accessed January 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, January 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
This Is What It's Like To Date A Med Student

This Is What It's Like To Date A Med Student

BuzzFeed (Jan. 23, 2015) Dating is now speed-dating... or studying. Video provided by BuzzFeed
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins