Featured Research

from universities, journals, and other organizations

New cancer target discovered: Mechanism by which PI3K sustains the proliferation of cancer cells

Date:
February 28, 2013
Source:
The Biochemical Society
Summary:
PI3K is a name given to a family of enzymes that are involved in cell growth, proliferation, differentiation and many other cellular functions. These enzymes are also implicated in many cancers and PI3K signalling is a target for treatments. Now, researchers have discovered a previously unrecognized mechanism by which PI3K sustains the proliferation of cancer cells. It appears that PI3K modulates the concentration of spermidine, a polyamine involved in cellular metabolism.

New research published today in the Biochemical Journal describes the discovery of a new cancer target.

PI3K is a name given to a family of enzymes that are involved in cell growth, proliferation, differentiation and many other cellular functions.

These enzymes are also implicated in many cancers and PI3K signalling is a target for treatments.

Now, researchers at Bart's Cancer Institute in London have discovered a previously unrecognized mechanism by which PI3K sustains the proliferation of cancer cells. It appears that PI3K modulates the concentration of spermidine, a polyamine involved in cellular metabolism.

Writing in the Biochemical Journal, the researchers explain that there are two biochemical pathways controlling each other's activities in a kind of feedback loop: that of the enzymes PI3K and ornithine decarboxylase. Restricting the action of both led to a dramatic shrinkage of tumours in xenograft models.

"Our work provides new insights into the intriguing interlink that exists between signalling and metabolic pathways and how these synergize in the development of cancers," said Dr Pedro Cutillas, of the Barts Cancer Institute, Queen Mary University of London, and one of the authors. "I hope this study will inspire new avenues in the exploration of cancer therapies that target metabolic and signalling pathways."


Story Source:

The above story is based on materials provided by The Biochemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vinothini Rajeeve, Wayne Pearce, Marta Cascante, Bart Vanhaesebroeck, PedroR. Cutillas. Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth. Biochemical Journal, 2013; 450 (3): 619 DOI: 10.1042/BJ20121525

Cite This Page:

The Biochemical Society. "New cancer target discovered: Mechanism by which PI3K sustains the proliferation of cancer cells." ScienceDaily. ScienceDaily, 28 February 2013. <www.sciencedaily.com/releases/2013/02/130228080246.htm>.
The Biochemical Society. (2013, February 28). New cancer target discovered: Mechanism by which PI3K sustains the proliferation of cancer cells. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2013/02/130228080246.htm
The Biochemical Society. "New cancer target discovered: Mechanism by which PI3K sustains the proliferation of cancer cells." ScienceDaily. www.sciencedaily.com/releases/2013/02/130228080246.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins