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Better understanding of peripheral neuropathy

March 5, 2013
University of Plymouth
Researchers have unlocked the key to a mechanism for peripheral neuropathy in people with multiple brain tumors.

One in 25,000 people worldwide is affected by neurofibromatosis type 2 (NF2), a condition where the loss of a tumour suppressor called Merlin results in multiple tumours in the brain and nervous system.

Sufferers may experience 20 to 30 tumours at any one time and such numbers often lead to hearing loss, disability and eventually death. Those with NF2 may also experience peripheral neuropathy, which is when the nerves carrying messages to and from the brain and spinal column to the rest of the body do not work.

Peripheral neuropathy leads to further complications for NF2 sufferers, such as pain and numbness, muscle problems, problems with body organs and other symptoms of nerve damage, such as bladder problems, uncontrollable sweating and sexual dysfunction.

Researchers from Plymouth University Peninsula Schools of Medicine and Dentistry are part of an international research team which has for the first time identified the role of a tumour suppressor called Merlin in regulating the integrity of axons. Axons are nerve fibres which transmit information around the body and it is these are that damaged in peripheral neuropathy.

The research team showed that Merlin regulates a protein called neurofilament which supplies structural support for the axon.

A better understanding of this mechanism could lead to effective drug therapies to alleviate the symptoms of peripheral neuropathy in patients with NF2.

The results of the research is published this week in Nature Neuroscience.

Story Source:

The above post is reprinted from materials provided by University of Plymouth. Note: Materials may be edited for content and length.

Journal Reference:

  1. Alexander Schulz, Stephan L Baader, Michiko Niwa-Kawakita, Marie Juliane Jung, Reinhard Bauer, Cynthia Garcia, Ansgar Zoch, Stephan Schacke, Christian Hagel, Victor-Felix Mautner, C Oliver Hanemann, Xin-Peng Dun, David B Parkinson, Joachim Weis, J Michael Schröder, David H Gutmann, Marco Giovannini, Helen Morrison. Merlin isoform 2 in neurofibromatosis type 2–associated polyneuropathy. Nature Neuroscience, 2013; DOI: 10.1038/nn.3348

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University of Plymouth. "Better understanding of peripheral neuropathy." ScienceDaily. ScienceDaily, 5 March 2013. <>.
University of Plymouth. (2013, March 5). Better understanding of peripheral neuropathy. ScienceDaily. Retrieved November 28, 2015 from
University of Plymouth. "Better understanding of peripheral neuropathy." ScienceDaily. (accessed November 28, 2015).

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