Featured Research

from universities, journals, and other organizations

Implementing HPV vaccinations at a young age is significant for vaccine effectiveness

Date:
March 13, 2013
Source:
Journal of the National Cancer Institute
Summary:
Initial vaccinations for human papillomavirus (HPV) at a young age is important for maximizing quadrivalent HPV vaccine effectiveness according to a Swedish study.

Initial vaccinations for human papillomavirus (HPV) at a young age is important for maximizing quadrivalent HPV vaccine effectiveness according to a Swedish study published March 13 in the Journal of the National Cancer Institute.

HPV vaccination programs have been launched around the world in hopes of preventing cervical cancer and other HPV-related cancers. While incidence of genital warts is the earliest possible disease outcome to measure the efficacy of the HPV vaccine, the results of such efficacy trials may not be fully generalizable to real-life HPV vaccination programs. Furthermore, incidence of genital warts after on-demand vaccination with quadrivalent HPV vaccine using individual-level data remains unknown.

In order to determine the efficacy of maximizing HPV vaccines at a young age, Amy Leval, R.N., of the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet in Stockholm, Sweden and colleagues, looked at a cohort of females ages 10 to 44 years living in Sweden between 2006-2010 who were linked to multiple population registers to identify genital warts incidence in relation to HPV vaccination. Incidence rate ratios of genital warts were estimated using time-to-event analyses with adjustment for attained age and parental education level, stratified by age at first vaccination.

The researchers found that of the cohort, females with at least one university-educated parent were 15 times more likely to be vaccinated for HPV before age 20 years than females whose parents had not completed high school. For females over the age of 20, the rates of genital warts incidence decreased among the unvaccinated, suggesting that women with a high risk of genital warts favorably used HPV vaccines. The authors note their limitations, however, saying, "Interpreting the crude estimates of effectiveness for those aged 20 years or older at first vaccination is difficult because we found evidence suggesting a self-selection bias with women at high risk preferentially seeking vaccination."

In an accompanying editorial, Jennifer S. Smith, Ph.D., M.P.H., of the Gillings School of Global Public Health, University of North Carolina, and Elisabete Weiderpass, Ph.D., of Karolinska Institutet, write that the low HPV vaccination coverage before the national school-based program in Sweden was implemented gave the opportunity to compare the incidence of genital warts in vaccinated cohorts with that in unvaccinated cohorts. "Future studies in Sweden -- and elsewhere where HPV vaccine coverage rates are high in target populations, such as Australia and Canada -- may need to compare vaccinated birth cohorts with older birth cohorts that were previously unvaccinated to evaluate the impact of vaccination on the population level."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Amy Leval, Eva Herweijer, Alexander Ploner, Sandra Eloranta, Julia Fridman Simard, Joakim Dillner, Cecilia Young, Eva Netterlid, Pδr Sparιn, and Lisen Arnheim-Dahlstrφm. Quadrivalent Human Papillomavirus Vaccine Effectiveness: A Swedish National Cohort Study. J Natl Cancer Inst, March 13, 2013 DOI: 10.1093/jnci/djt032

Cite This Page:

Journal of the National Cancer Institute. "Implementing HPV vaccinations at a young age is significant for vaccine effectiveness." ScienceDaily. ScienceDaily, 13 March 2013. <www.sciencedaily.com/releases/2013/03/130313182150.htm>.
Journal of the National Cancer Institute. (2013, March 13). Implementing HPV vaccinations at a young age is significant for vaccine effectiveness. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2013/03/130313182150.htm
Journal of the National Cancer Institute. "Implementing HPV vaccinations at a young age is significant for vaccine effectiveness." ScienceDaily. www.sciencedaily.com/releases/2013/03/130313182150.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) — Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) — Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins