Featured Research

from universities, journals, and other organizations

Rigid growth matrix: A key to success of cardiac tissue engineering

Date:
April 15, 2013
Source:
National Institute for Materials Science
Summary:
A new study suggests that the elasticity of the physical matrix used for growing heart muscle cells outside of the body may be critical to the success of cardiac tissue engineering.

A new study by researchers at UCLA suggests that the elasticity of the physical matrix used for growing heart muscle cells outside of the body may be critical to the success of cardiac tissue engineering. The results were published in the journal Science and Technology of Advanced Materials this week.

Related Articles


Adult heart muscle is the least regenerative of human tissues. But embryonic cardiomyocytes (cardiac muscle cells) can multiply, with embryonic stem cells providing an endless reservoir for new cardiac tissue. A new study by Nakano, Gimzewski and their co-workers at the University of California, Los Angeles (UCLA) suggests that the elasticity of the physical matrix used for growing cardiomyocytes outside of the body may be critical to the success of cardiac tissue engineering efforts.

Published in the journal Science and Technology of Advanced Materials, the study found that a stiff or rigid environment not only enhances the function of existing cardiomyocytes (as has previously been shown), but also promotes the generation of cardiomyocytes from embryonic stem (ES) cells. It may therefor be possible to grow new heart muscle tissue from stem cells by manipulating the stiffness of the medium they're grown in.

In living organisms, a type of adult stem cells called mesenchymal stem cells (MSCs) are extremely sensitive to the elasticity of different materials, when cultured outside the body. For example, soft growing matrices that mimic brain tissue promote the differentiation of MSCs into neurons, while rigid matrices that resemble bone tissue promote the differentiation of MSCs into bone cells.

In this study, the UCLA team examined the role of matrix elasticity on cardiac muscle development using mouse and human embryonic stem cells, which were grown on different substrates of a silicon-based organic polymer that varied in stiffness. The team found that rigid matrices promoted the generation of more cardiomyocytes cells from ES cells. In addition, ES-derived cardiomyocytes displayed functional maturity and synchronization of beating when cultured with cardiomyocytes harvested from a developing embryo.

The team recommends further research on how biophysical cues determine the fate of embryonic stem cells in order to improve cardiac tissue culture methods for regenerative medicine purposes.


Story Source:

The above story is based on materials provided by National Institute for Materials Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Armin Arshi, Yasuhiro Nakashima, Haruko Nakano, Sarayoot Eaimkhong, Denis Evseenko, Jason Reed, Adam Z Stieg, James K Gimzewski, Atsushi Nakano. Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. Science and Technology of Advanced Materials, 2013; 14 (2): 025003 DOI: 10.1088/1468-6996/14/2/025003

Cite This Page:

National Institute for Materials Science. "Rigid growth matrix: A key to success of cardiac tissue engineering." ScienceDaily. ScienceDaily, 15 April 2013. <www.sciencedaily.com/releases/2013/04/130415123605.htm>.
National Institute for Materials Science. (2013, April 15). Rigid growth matrix: A key to success of cardiac tissue engineering. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2013/04/130415123605.htm
National Institute for Materials Science. "Rigid growth matrix: A key to success of cardiac tissue engineering." ScienceDaily. www.sciencedaily.com/releases/2013/04/130415123605.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins