Featured Research

from universities, journals, and other organizations

Testing lung cancer drugs and therapies in mice

Date:
April 17, 2013
Source:
NIH/National Cancer Institute
Summary:
Researchers have designed a genetically engineered mouse for use in the study of human lung squamous cell carcinoma (SCC).

National Cancer Institute (NCI) investigators have designed a genetically engineered mouse for use in the study of human lung squamous cell carcinoma (SCC).

Related Articles


SCC is a type of non-small cell lung carcinoma, one of the most common types of lung cancer, with a five-year survival rate of about 15 percent. The investigators designed mouse models because they are an essential part of drug development, often the first step after laboratory experiments. The results of this study, headed by Yinling Hu, Ph.D., an investigator in the Laboratory of Experimental Immunology, Center for Cancer Research, NCI, appeared in Cancer Cell, April 15, 2013.

Scientists in this study designed their mouse models to identify molecular targets, such as IKK-alpha (IKK-α), which is a type of enzyme involved in regulating cellular growth, survival and immunity. For more than 10 years, work in Hu’s laboratory has focused on understanding IKK-α’s developmental function in keratinocytes (a type of cell that can give rise to SCC in the skin) by using mice genetically modified by IKK-α deletion, mutation and/or overexpression of IKK-α.

In this study, Hu and colleagues searched for similarities between human and mouse lung SCCs at both the level of the lung SCC cells themselves, as well as the tumor microenvironment in the lungs. As a result, they found that IKK-α reduction elevates levels of cancer-causing proteins, and lowers levels of tumor suppressive proteins in lung SCCs. Further, the mice with the IKK-α reduction exhibited an increase of inflammatory cells in their lungs, which contributed to the initiation and development of lung SCC.


Story Source:

The above story is based on materials provided by NIH/National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zuoxiang Xiao, Qun Jiang, Jami Willette-Brown, Sichuan Xi, Feng Zhu, Sandra Burkett, Timothy Back, Na-Young Song, Mahesh Datla, Zhonghe Sun, Romina Goldszmid, Fanching Lin, Travis Cohoon, Kristen Pike, Xiaolin Wu, David S. Schrump, Kwok-Kin Wong, Howard A. Young, Giorgio Trinchieri, Robert H. Wiltrout, Yinling Hu. The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas. Cancer Cell, 2013; 23 (4): 527 DOI: 10.1016/j.ccr.2013.03.009

Cite This Page:

NIH/National Cancer Institute. "Testing lung cancer drugs and therapies in mice." ScienceDaily. ScienceDaily, 17 April 2013. <www.sciencedaily.com/releases/2013/04/130417113914.htm>.
NIH/National Cancer Institute. (2013, April 17). Testing lung cancer drugs and therapies in mice. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/04/130417113914.htm
NIH/National Cancer Institute. "Testing lung cancer drugs and therapies in mice." ScienceDaily. www.sciencedaily.com/releases/2013/04/130417113914.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins