Featured Research

from universities, journals, and other organizations

Testing lung cancer drugs and therapies in mice

Date:
April 17, 2013
Source:
NIH/National Cancer Institute
Summary:
Researchers have designed a genetically engineered mouse for use in the study of human lung squamous cell carcinoma (SCC).

National Cancer Institute (NCI) investigators have designed a genetically engineered mouse for use in the study of human lung squamous cell carcinoma (SCC).

SCC is a type of non-small cell lung carcinoma, one of the most common types of lung cancer, with a five-year survival rate of about 15 percent. The investigators designed mouse models because they are an essential part of drug development, often the first step after laboratory experiments. The results of this study, headed by Yinling Hu, Ph.D., an investigator in the Laboratory of Experimental Immunology, Center for Cancer Research, NCI, appeared in Cancer Cell, April 15, 2013.

Scientists in this study designed their mouse models to identify molecular targets, such as IKK-alpha (IKK-α), which is a type of enzyme involved in regulating cellular growth, survival and immunity. For more than 10 years, work in Hu’s laboratory has focused on understanding IKK-α’s developmental function in keratinocytes (a type of cell that can give rise to SCC in the skin) by using mice genetically modified by IKK-α deletion, mutation and/or overexpression of IKK-α.

In this study, Hu and colleagues searched for similarities between human and mouse lung SCCs at both the level of the lung SCC cells themselves, as well as the tumor microenvironment in the lungs. As a result, they found that IKK-α reduction elevates levels of cancer-causing proteins, and lowers levels of tumor suppressive proteins in lung SCCs. Further, the mice with the IKK-α reduction exhibited an increase of inflammatory cells in their lungs, which contributed to the initiation and development of lung SCC.


Story Source:

The above story is based on materials provided by NIH/National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zuoxiang Xiao, Qun Jiang, Jami Willette-Brown, Sichuan Xi, Feng Zhu, Sandra Burkett, Timothy Back, Na-Young Song, Mahesh Datla, Zhonghe Sun, Romina Goldszmid, Fanching Lin, Travis Cohoon, Kristen Pike, Xiaolin Wu, DavidS. Schrump, Kwok-Kin Wong, HowardA. Young, Giorgio Trinchieri, RobertH. Wiltrout, Yinling Hu. The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas. Cancer Cell, 2013; 23 (4): 527 DOI: 10.1016/j.ccr.2013.03.009

Cite This Page:

NIH/National Cancer Institute. "Testing lung cancer drugs and therapies in mice." ScienceDaily. ScienceDaily, 17 April 2013. <www.sciencedaily.com/releases/2013/04/130417113914.htm>.
NIH/National Cancer Institute. (2013, April 17). Testing lung cancer drugs and therapies in mice. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2013/04/130417113914.htm
NIH/National Cancer Institute. "Testing lung cancer drugs and therapies in mice." ScienceDaily. www.sciencedaily.com/releases/2013/04/130417113914.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins