Featured Research

from universities, journals, and other organizations

New understanding of asthma development: Transmission of respiratory viruses in utero

Date:
April 18, 2013
Source:
Cleveland Clinic
Summary:
The most common cause of lower respiratory tract infections in infants and young children, respiratory syncytial virus, can be transferred during pregnancy to an unborn baby, according to new research.

The most common cause of lower respiratory tract infections in infants and young children, respiratory syncytial virus (RSV), can be transferred during pregnancy to an unborn baby, according to Cleveland Clinic Children's Hospital research published online this week in the journal PLOS ONE.

In animal models, the study shows that RSV is able to spread across the placenta from the respiratory tract of the mother to the fetus, and is present in the lungs after birth, throughout development and into adulthood. RSV is considered the primary cause of infant pneumonia and has been implicated in the development of asthma.

"Epidemiologic evidence suggests that early-life RSV infection predisposes children to recurrent wheezing and asthma," said Giovanni Piedimonte, M.D., the study's lead author and Chairman of Cleveland Clinic Children's Hospital and the Pediatric Institute. "This study challenges the current paradigm that RSV infection is acquired only after birth and shifts attention to prenatal effects of the virus, which may result in more severe and lasting consequences by interfering with an unborn baby's critical developmental processes."

Research was completed in an animal model, in which rats were inoculated with RSV during midterm pregnancy. Of those infected, RSV was found in 30 percent of fetuses, as well as in the lungs of 40 percent of newborns and 25 percent of those that reached adulthood.

Dr. Piedimonte has been the principal investigator or co-investigator of more than 30 research projects, and has authored and co-authored more than 250 journal articles, book chapters, monographs, editorials and abstracts. He holds 17 international patents and is frequently invited to speak nationally and internationally.


Story Source:

The above story is based on materials provided by Cleveland Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Giovanni Piedimonte, Cheryl Walton, Lennie Samsell. Vertical Transmission of Respiratory Syncytial Virus Modulates Pre- and Postnatal Innervation and Reactivity of Rat Airways. PLoS ONE, 2013; 8 (4): e61309 DOI: 10.1371/journal.pone.0061309

Cite This Page:

Cleveland Clinic. "New understanding of asthma development: Transmission of respiratory viruses in utero." ScienceDaily. ScienceDaily, 18 April 2013. <www.sciencedaily.com/releases/2013/04/130418214051.htm>.
Cleveland Clinic. (2013, April 18). New understanding of asthma development: Transmission of respiratory viruses in utero. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2013/04/130418214051.htm
Cleveland Clinic. "New understanding of asthma development: Transmission of respiratory viruses in utero." ScienceDaily. www.sciencedaily.com/releases/2013/04/130418214051.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins