Featured Research

from universities, journals, and other organizations

New understanding of asthma development: Transmission of respiratory viruses in utero

Date:
April 18, 2013
Source:
Cleveland Clinic
Summary:
The most common cause of lower respiratory tract infections in infants and young children, respiratory syncytial virus, can be transferred during pregnancy to an unborn baby, according to new research.

The most common cause of lower respiratory tract infections in infants and young children, respiratory syncytial virus (RSV), can be transferred during pregnancy to an unborn baby, according to Cleveland Clinic Children's Hospital research published online this week in the journal PLOS ONE.

Related Articles


In animal models, the study shows that RSV is able to spread across the placenta from the respiratory tract of the mother to the fetus, and is present in the lungs after birth, throughout development and into adulthood. RSV is considered the primary cause of infant pneumonia and has been implicated in the development of asthma.

"Epidemiologic evidence suggests that early-life RSV infection predisposes children to recurrent wheezing and asthma," said Giovanni Piedimonte, M.D., the study's lead author and Chairman of Cleveland Clinic Children's Hospital and the Pediatric Institute. "This study challenges the current paradigm that RSV infection is acquired only after birth and shifts attention to prenatal effects of the virus, which may result in more severe and lasting consequences by interfering with an unborn baby's critical developmental processes."

Research was completed in an animal model, in which rats were inoculated with RSV during midterm pregnancy. Of those infected, RSV was found in 30 percent of fetuses, as well as in the lungs of 40 percent of newborns and 25 percent of those that reached adulthood.

Dr. Piedimonte has been the principal investigator or co-investigator of more than 30 research projects, and has authored and co-authored more than 250 journal articles, book chapters, monographs, editorials and abstracts. He holds 17 international patents and is frequently invited to speak nationally and internationally.


Story Source:

The above story is based on materials provided by Cleveland Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Giovanni Piedimonte, Cheryl Walton, Lennie Samsell. Vertical Transmission of Respiratory Syncytial Virus Modulates Pre- and Postnatal Innervation and Reactivity of Rat Airways. PLoS ONE, 2013; 8 (4): e61309 DOI: 10.1371/journal.pone.0061309

Cite This Page:

Cleveland Clinic. "New understanding of asthma development: Transmission of respiratory viruses in utero." ScienceDaily. ScienceDaily, 18 April 2013. <www.sciencedaily.com/releases/2013/04/130418214051.htm>.
Cleveland Clinic. (2013, April 18). New understanding of asthma development: Transmission of respiratory viruses in utero. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2013/04/130418214051.htm
Cleveland Clinic. "New understanding of asthma development: Transmission of respiratory viruses in utero." ScienceDaily. www.sciencedaily.com/releases/2013/04/130418214051.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins