Featured Research

from universities, journals, and other organizations

Anti-depressant link to Clostridium difficile infection

Date:
May 7, 2013
Source:
BioMed Central Limited
Summary:
Certain types of anti-depressants have been linked to an increase in the risk of Clostridium difficile infection (CDI) finds a new study. Awareness of this link should improve identification and early treatment of CDI.

Certain types of anti-depressants have been linked to an increase in the risk of Clostridium difficile infection (CDI) finds a study in BioMed Central's open access journal BMC Medicine. Awareness of this link should improve identification and early treatment of CDI.

CDI is one of the most common hospital acquired infections and is responsible for more than 7000 deaths annually in the USA alone. Several types of medications are thought to increase risk of CDI, including anti-depressants, and given that depression is the third most common medical condition worldwide a team from the University of Michigan investigated the exact nature of this risk.

Firstly the team studied Clostridium difficile infection in people with and without depression and found that people with major depression had a much higher chance of CDI (a 36% increase) than people without depression. This association held for a variety of depressive disorders and nervous or psychiatric problems. Age and family support also impacted risk of CDI. Older, widowed Americans were 54% more likely to catch C. difficile than their married peers. Just living alone increased risk by 25%.

Secondly they looked to see if there was an association between antidepressant medication and hospital acquired CDI. They found that use of most types of antidepressants did not affect CDI risk -- out of the twelve drugs tested only mirtazapine and fluoxetine increased risk of CDI, in each case the risk was doubled.

People who have been prescribed these types of anti-depressants need to keep taking them unless otherwise advised by their physician. The researchers stress that it is not yet known whether the increase in CDI is due to microbial changes in the gut during depression or to the medications associated with depression.

Dr. Mary Rogers who led this study explained, "Depression is common worldwide. We have long known that depression is associated with changes in the gastrointestinal system. The interaction between the brain and the gut, called the "brain-gut axis" is fascinating and deserves more study. Our finding of a link between depression and Clostridium difficile should help us better identify those at risk of infection and perhaps, encourage exploration of the underlying brain-gut mechanisms involved."


Story Source:

The above story is based on materials provided by BioMed Central Limited. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao and David M Aronoff. Depression, antidepressant medications, and risk of Clostridium difficile infection. BMC Medicine, 2013, 11:121 DOI: 10.1186/1741-7015-11-121

Cite This Page:

BioMed Central Limited. "Anti-depressant link to Clostridium difficile infection." ScienceDaily. ScienceDaily, 7 May 2013. <www.sciencedaily.com/releases/2013/05/130507061048.htm>.
BioMed Central Limited. (2013, May 7). Anti-depressant link to Clostridium difficile infection. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2013/05/130507061048.htm
BioMed Central Limited. "Anti-depressant link to Clostridium difficile infection." ScienceDaily. www.sciencedaily.com/releases/2013/05/130507061048.htm (accessed August 30, 2014).

Share This




More Mind & Brain News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

Ivanhoe (Aug. 27, 2014) It’s an unusual condition with a colorful name. Kids with “Alice in Wonderland” syndrome see sudden distortions in objects they’re looking at or their own bodies appear to change size, a lot like the main character in the Lewis Carroll story. Video provided by Ivanhoe
Powered by NewsLook.com
Stopping Schizophrenia Before Birth

Stopping Schizophrenia Before Birth

Ivanhoe (Aug. 27, 2014) Scientists have long called choline a “brain booster” essential for human development. Not only does it aid in memory and learning, researchers now believe choline could help prevent mental illness. Video provided by Ivanhoe
Powered by NewsLook.com
Personalized Brain Vaccine for Glioblastoma

Personalized Brain Vaccine for Glioblastoma

Ivanhoe (Aug. 27, 2014) Glioblastoma is the most common and aggressive brain cancer in humans. Now a new treatment using the patient’s own tumor could help slow down its progression and help patients live longer. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins