Featured Research

from universities, journals, and other organizations

Infection and sepsis-related mortality hotspots identified across the U.S.

Date:
May 15, 2013
Source:
Perelman School of Medicine at the University of Pennsylvania
Summary:
In the past, researchers have sought to determine the geographic distribution of many life-threatening conditions, including stroke and cardiac arrest. Now, researchers have created the first U.S. map that pinpoints hotspots for infection and severe sepsis related-deaths -- with notable clusters located in the Midwest, mid-Atlantic, and the South. The research is a critical first step in helping to determine which areas of the country require vital public health resources to fight these deadly diseases.

Researchers at the Perelman School of Medicine at the University of Pennsylvania have created the first U.S. map that pinpoints hotspots for infection and severe sepsis related-deaths.
Credit: Penn Medicine

In the past, researchers have sought to determine the geographic distribution of many life-threatening conditions, including stroke and cardiac arrest. Now, researchers at the Perelman School of Medicine at the University of Pennsylvania have created the first U.S. map that pinpoints hotspots for infection and severe sepsis related-deaths -- with notable clusters located in the Midwest, mid-Atlantic, and the South. The research is a critical first step in helping to determine which areas of the country require vital public health resources to fight these deadly diseases.

The new research will be presented at the annual meeting of Society for Academic Emergency Medicine in Atlanta, Ga.

"Infection-related deaths are a leading cause of morbidity and mortality in the U.S., affecting over 1 million people a year, and costing $17 billion annually," said lead study author David Gaieski, MD, an associate professor of Emergency Medicine at Penn. "And while our understanding of the causes of infection-related death rates has improved, we are still struggling to prevent these diseases and identify individuals who are most susceptible. We need to be able to pinpoint the geographic distribution of infection-related death rates in order to further study how and why these infections are happening in these areas and the best methods to prevent these deaths."

Sepsis is the tenth leading cause of death in the United States. With an estimated 750,000 cases annually and a nearly 40 percent mortality rate, severe sepsis is also one of the most common causes of death in hospital critical care units.

To better understand what areas of the country are most at risk for severe sepsis and other infection-related deaths, the research team collected U.S. county death data from the 2010 Multiple Cause of Death data files (compiled by the National Center for Health Statistics) and combined it with 2010 Area Resource File demographic data for a comprehensive view of national variations. The authors note that previous research had only been able to identify potential trends on a state level.

Infection-related deaths were identified using ICD-10 primary cause of death codes for infection and severe sepsis. "Hotspots" were defined as regions where the infection death rate was significantly higher than the national mean and surrounding counties. The analysis revealed four hotspots: 1) two regions that had three times the national mean of infection-related deaths located across the Midwest and mid-Atlantic and 2) two regions that had four times the national death rate from severe sepsis, located in the South and mid-Atlantic.

In addition to the hotspots, the research team also identified one "coolspot" cluster, an area that had disproportionately low rates of deaths caused by these infections. The coolspot cluster consisted of 157 counties located across the Southwest and Mountain states. The research team notes that these "coolspot" counties might yield important insights as well, including particular screening and treatment protocols that may be in place in these areas.

"This analysis may help target focused geographical interventions to improve the dissemination and implementation of evidence-based care," said senior study author Brendan G. Carr, MD, MA, assistant professor of Emergency Medicine, Surgery, & Epidemiology at Penn. "Further study is required to clarify the geographic variability we observed, but we believe this new resource will be a helpful tool for researchers and public health officials."

Additional authors from Penn include Anish Agarwal, MD, MPH, Catherine S. Wolff, Douglas Wiebe, PhD, and Mark E. Mikkelsen, MD.


Story Source:

The above story is based on materials provided by Perelman School of Medicine at the University of Pennsylvania. Note: Materials may be edited for content and length.


Cite This Page:

Perelman School of Medicine at the University of Pennsylvania. "Infection and sepsis-related mortality hotspots identified across the U.S.." ScienceDaily. ScienceDaily, 15 May 2013. <www.sciencedaily.com/releases/2013/05/130515113717.htm>.
Perelman School of Medicine at the University of Pennsylvania. (2013, May 15). Infection and sepsis-related mortality hotspots identified across the U.S.. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2013/05/130515113717.htm
Perelman School of Medicine at the University of Pennsylvania. "Infection and sepsis-related mortality hotspots identified across the U.S.." ScienceDaily. www.sciencedaily.com/releases/2013/05/130515113717.htm (accessed July 29, 2014).

Share This




More Science & Society News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
The Carbon Trap: US Exports Global Warming

The Carbon Trap: US Exports Global Warming

AP (July 28, 2014) AP Investigation: As the Obama administration weans the country off dirty fuels, energy companies are ramping-up overseas coal exports at a heavy price. (July 28) Video provided by AP
Powered by NewsLook.com
Russia Saves Gecko Sex Satellite, Media Has Some Fun With It

Russia Saves Gecko Sex Satellite, Media Has Some Fun With It

Newsy (July 27, 2014) The satellite is back under ground control after a tense few days, but with a gecko sex experiment on board, the media just couldn't help themselves. Video provided by Newsy
Powered by NewsLook.com
Cellphone Unlocking Bill Clears U.S. House, Heads to Obama

Cellphone Unlocking Bill Clears U.S. House, Heads to Obama

Reuters - US Online Video (July 27, 2014) Congress gets rid of pesky law that made it illegal to "unlock" mobile phones without permission, giving consumers the option to use the same phone on a competitor's wireless network. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins