Featured Research

from universities, journals, and other organizations

Inflammation links social adversity and diabetes

Date:
July 2, 2013
Source:
Public Library of Science
Summary:
Diabetes is strongly associated with socioeconomic status: Low income, low education, and low occupational status are all linked to a higher risk for diabetes. Trying to understand the mechanisms underlying the association, researchers report that a substantial part of it appears to be attributable to chronic inflammation.

Diabetes is strongly associated with socioeconomic status (SES): low income, low education, and low occupational status are all linked to a higher risk for diabetes. Trying to understand the mechanisms underlying the association, Silvia Stringhini from the Institute for Social and Preventive Medicine in Lausanne, Switzerland and colleagues report in this week's PLOS Medicine that a substantial part of it appears to be attributable to chronic inflammation.

Related Articles


"Taking together the evidence linking socioeconomic adversity to inflammation and inflammation to type 2 diabetes" the authors write, "it seems reasonable to postulate that chronically increased inflammatory activity in individuals exposed to socioeconomic adversity over the entire lifecourse may, at least partially, mediate the association between socioeconomic status over the lifecourse and future type 2 diabetes risk."

To test their hypothesis, they analyzed data from the Whitehall II study. Following the famous original Whitehall study that pioneered the study of social determinants of health, Whitehall II has followed over 10,000 participants, all British civil servants working in London, since the mid 1980s. The study is ongoing, and participants undergo regular health check-ups and also provide extensive information about their social situation every few years.

For their study, the researchers focused on 6387 participants who had provided information on their education level and current occupation (reflective of early adulthood and present socio-economic status, respectively) as well as their father's occupation (a proxy for childhood socio-economic status). In addition, it was known which of the participants had developed diabetes and when, and whether and when their blood work had shown signs of chronic inflammation.

They found that cumulative exposure to low SES over the lifecourse and a downward trajectory from high SES in childhood to low SES in adulthood were associated with an increased risk of developing type 2 diabetes over the study period. In addition, inflammatory processes, measured repeatedly through biomarkers in the blood, explained as much as one third of this association.

"Assuming that our findings reflect a causal association," the authors say, "our results suggest that tackling socioeconomic differences in inflammation, especially among the most disadvantaged groups, might reduce social inequalities in type 2 diabetes."

They suggest that future studies should test interventions that reduce chronic inflammation, as "(such studies) will be necessary to determine the extent to which social inequalities attributable to chronic inflammation are reversible."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Silvia Stringhini, G. David Batty, Pascal Bovet, Martin J. Shipley, Michael G. Marmot, Meena Kumari, Adam G. Tabak, Mika Kivimδki. Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study. PLoS Medicine, 2013; 10 (7): e1001479 DOI: 10.1371/journal.pmed.1001479

Cite This Page:

Public Library of Science. "Inflammation links social adversity and diabetes." ScienceDaily. ScienceDaily, 2 July 2013. <www.sciencedaily.com/releases/2013/07/130702173152.htm>.
Public Library of Science. (2013, July 2). Inflammation links social adversity and diabetes. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2013/07/130702173152.htm
Public Library of Science. "Inflammation links social adversity and diabetes." ScienceDaily. www.sciencedaily.com/releases/2013/07/130702173152.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins