Featured Research

from universities, journals, and other organizations

Chemical/bioengineers use adhesion to combine advantages of silicones and organic materials

Date:
July 9, 2013
Source:
Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Summary:
Bioengineers have found a way to strongly adhere hydrogels to hydrophobic silicone substrates, an innovation that provides a valuable new tool for microscale biotechnology.

Introductory chemistry students learn that oil and water repel each other. So do other hydrophobic substances, which carry no electric charge, and hydrophilic substances, which carry an electric charge that allows them to mix with water.

Related Articles


In a study reported in the July 1, 2013 Angewandte Chemie, a group of University of Illinois bioengineers have found a way to strongly adhere hydrogels to hydrophobic silicone substrates, an innovation that provides a valuable new tool for microscale biotechnology. The article reporting the work was highlighted by the editors as a "Hot Paper" in Soft Material Chemistry.

Microscale biotechnologies, including cell culture platforms and biochips, have important applications in genomics, tissue engineering, and many other areas of biology. Silicone polymers are often used as a component material in these technologies because of their advantageous properties: silicones are inert, elastic, biocompatible, and easy to work with.

One major drawback of this type of material in biological applications is that surfaces formed by silicones are extremely hydrophobic. These surfaces therefore prohibit easy flow of aqueous solutions and prevent the binding of some biomolecules, while promoting undesired binding of others. Chemical modifications or coatings can be used to make the surfaces hydrophilic, but the results produced by these treatments are temporary.

The Illinois study, led by Hyunjoon Kong, Assistant Professor of Chemical and Biomolecular Engineering and member of the Regenerative Biology and Tissue Engineering research theme at the Institute for Genomic Biology, addressed this problem. The group worked to develop a method to permanently modify a silicone polymer surface. Kong's group sought a way to "glue" an alginate hydrogel, a water-absorbing substance also used in food and medical industries, to a surface formed by polydimethylsiloxane (PDMS), a silicone polymer that is a common material in microscale biotechnologies.

"It has been often suggested that integration of the silicone-based materials with organic, tissue-like hydrogel materials should enhance functionality," says Kong. "However, it was a grand challenge to attain and sustain adhesion between two disparate materials."

The solution, developed by first author Chaenyung Cha, Kong, and others, was to develop a multi-step protocol to covalently link alginate, the polysaccharide that is also a component of the hydrogel, to a PDMS surface. The resulting alginate-PDMS can then participate in a cross-linking reaction that forms an alginate hydrogel. Tests performed as part of the study showed that the attachment of hydrogel to PDMS formed by this process is stable for several months, can tolerate bending and repeated stretching, and is not degraded by aqueous solutions. The hydrogel is more hydrophilic than the surfaces produced by previously developed treatments, and its physical properties can be easily controlled by modifying the crosslinking reaction used in its formation.

The study also explored several practical applications of the hydrogel-PDMS surface. Fibroblasts, a type of cells found in connective tissue, were first cultured on a hydrogel-PDMS surface, and then chronically exposed to repeated stretching. This type of manipulation would not be possible with less elastic cell culture substrates, and has value for researchers studying the effects of mechanical stress on living cells inside the body.

Another experiment showed that the hydrogel could be successfully and stably synthesized within the channels of a microfluidic device. "This method will greatly advance quality of cell culture platforms and microfluidic devices. It will further benefit design of novel drug delivery systems and cell transplantation devices," Kong said.


Story Source:

The above story is based on materials provided by Institute for Genomic Biology, University of Illinois at Urbana-Champaign. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chaenyung Cha, Eleni Antoniadou, Minkyung Lee, Jae Hyun Jeong, Wylie W. Ahmed, Taher A. Saif, Stephen A. Boppart, Hyunjoon Kong. Tailoring Hydrogel Adhesion to Polydimethylsiloxane Substrates Using Polysaccharide Glue. Angewandte Chemie International Edition, 2013; 52 (27): 6949 DOI: 10.1002/anie.201302925

Cite This Page:

Institute for Genomic Biology, University of Illinois at Urbana-Champaign. "Chemical/bioengineers use adhesion to combine advantages of silicones and organic materials." ScienceDaily. ScienceDaily, 9 July 2013. <www.sciencedaily.com/releases/2013/07/130709143530.htm>.
Institute for Genomic Biology, University of Illinois at Urbana-Champaign. (2013, July 9). Chemical/bioengineers use adhesion to combine advantages of silicones and organic materials. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2013/07/130709143530.htm
Institute for Genomic Biology, University of Illinois at Urbana-Champaign. "Chemical/bioengineers use adhesion to combine advantages of silicones and organic materials." ScienceDaily. www.sciencedaily.com/releases/2013/07/130709143530.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microsoft Adds Robot Guards, Ushers In Sci-Fi Apocalypse

Microsoft Adds Robot Guards, Ushers In Sci-Fi Apocalypse

Newsy (Nov. 23, 2014) Microsoft has robotic security guards working at its Silicon Valley Campus. Video provided by Newsy
Powered by NewsLook.com
Toyota's Hydrogen Fuel-Cell Green Car Soon Available in the US

Toyota's Hydrogen Fuel-Cell Green Car Soon Available in the US

AFP (Nov. 21, 2014) Toyota presented its hydrogen fuel-cell compact car called "Mirai" to US consumers at the Los Angeles auto show. The car should go on sale in 2015 for around $60.000. It combines stored hydrogen with oxygen to generate its own power. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Google Announces Improvements To Balloon-Borne Wi-Fi Project

Google Announces Improvements To Balloon-Borne Wi-Fi Project

Newsy (Nov. 21, 2014) In a blog post, Google said its balloons have traveled 3 million kilometers since the start of Project Loon. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins