Featured Research

from universities, journals, and other organizations

Researchers regenerate retina in mice using neuronal reprogramming

Date:
July 11, 2013
Source:
Centre for Genomic Regulation
Summary:
Researchers in Spain have managed to regenerate the retina in mice using neuronal reprogramming. There are currently several lines of research that explore the possibility of tissue regeneration through cell reprogramming. One of the mechanisms being studied is reprogramming through cell fusion.

Researchers from the Centre for Genomic Regulation (CRG) in Barcelona have managed to regenerate the retina in mice using neuronal reprogramming. There are currently several lines of research that explore the possibility of tissue regeneration through cell reprogramming. One of the mechanisms being studied is reprogramming through cell fusion.

The researcher Pia Cosma and her team have used the cell fusion mechanism to reprogram the neurons in the retina. This mechanism consists of introducing bone marrow stem cells into the damaged retina. The new undifferentiated cells fuse with the retinal neurons and these acquire the ability to regenerate the tissue.

"For the first time we have managed to regenerate the retina and reprogram its neurons through in vivo cell fusion. We have identified a signalling pathway that, once activated, allows the neurons to be reprogrammed through their fusion with bone marrow cells," explains Pia Cosma, head of the Reprogramming and Regeneration group at the Centre for Genomic Regulation and ICREA research professor. "This discovery is important not only because of the possible medical applications for retinal regeneration but also for the possible regeneration of other nervous tissues," says Daniela Sanges, first author of the work and postdoctoral researcher in Pia Cosma's laboratory.

The study, published by the journal Cell Reports, demonstrates that the regeneration of nervous tissue by means of cell fusion is possible in mammals and describes this new technique as a potential mechanism for the regeneration of more complex nervous tissue.

This research is in the very early stages but already there are laboratories interested in being able to continue the work and take it to a more applied level.


Story Source:

The above story is based on materials provided by Centre for Genomic Regulation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Daniela Sanges, Neus Romo, Giacoma Simonte, Umberto Di Vicino, Ariadna Diaz Tahoces, Eduardo Fernαndez, and Maria Pia Cosma. Wnt/β-Catenin Signaling Triggers Neuron Reprogramming and Regeneration in the Mouse Retina. Cell Reports, 2013; DOI: 10.1016/j.celrep.2013.06.015

Cite This Page:

Centre for Genomic Regulation. "Researchers regenerate retina in mice using neuronal reprogramming." ScienceDaily. ScienceDaily, 11 July 2013. <www.sciencedaily.com/releases/2013/07/130711134715.htm>.
Centre for Genomic Regulation. (2013, July 11). Researchers regenerate retina in mice using neuronal reprogramming. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2013/07/130711134715.htm
Centre for Genomic Regulation. "Researchers regenerate retina in mice using neuronal reprogramming." ScienceDaily. www.sciencedaily.com/releases/2013/07/130711134715.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins