Featured Research

from universities, journals, and other organizations

Physicists offer novel insight into experimental cancer treatment

Date:
July 15, 2013
Source:
University of York
Summary:
Physicists have carried out new research into how the heating effect of an experimental cancer treatment works. 

A Transmission Electron Microscope (TEM) image of the new particles produced by Liquids Research Ltd for hyperthermia applications.
Credit: Liquids Research Ltd

Physicists from the University of York have carried out new research into how the heating effect of an experimental cancer treatment works.

Magnetic hyperthermia is viewed as an attractive approach for the treatment of certain cancers as it has no known side effects compared to more conventional therapies such as chemotherapy. It is particularly suitable for the treatment of prostate cancer and brain tumours. However, until now there has been no clear theoretical understanding of how it actually works.

Treatment by magnetic hyperthermia involves injecting magnetic nanoparticles directly into a tumour then placing the patient in a machine which produces an alternating magnetic field. The nanoparticles oscillate and heat is produced inside the tumour tissue. When the temperature rises above 42ēC cells begin to die. This heating process has been demonstrated to reduce tumour size.

The study, by researchers from the University of York's Department of Physics and Liquids Research Ltd, of Bangor, North Wales, showed that the amount of heat generated by magnetic nanoparticles can be understood when both the physical and hydrodynamic size distributions for the samples are known to high accuracy.

The results of the study are published in the 'Journal of Physics D: Applied Physics' as a fast track communication. Lead author Dr Gonzalo Vallejo-Fernandez, from York's Department of Physics, said: "While clinical trials have shown the potential of magnetic nanoparticles for cancer treatment, the mechanisms by which the heat is generated have not been fully understood. This understanding is critical to produce particles with optimised properties for specific applications at minimal dose."

Previously the heat generated was impossible to predict as several mechanisms were involved. The new work has identified and quantified the mechanisms so that work can now begin to determine the dosage required for effective treatment.

Dr Vallejo-Fernandez said: "Through our study we have produced the first comprehensive assessment of how the heating effect in magnetic hyperthermia works. We are now in a position where we can do further work to calculate accurately the dose of magnetic nanoparticles and length of treatment required."

For the study, the researchers used magnetic nanoparticles produced by a new technique by Liquids Research Ltd, which was developed under the EU project MULTIFUN (Multifunctional Nanotechnology for Selective Detection and Treatment of Cancer). The nanoparticles are very uniform in size and well separated, which enabled detailed experiments to be performed which broadly confirmed the accuracy of the calculations.

Dr Vijay Patel, Director of Liquids Research Ltd, said: "The development of this new theory coincided with our work on the new process to fabricate the nanoparticles enabling us to 'design' almost ideal particles for this application."


Story Source:

The above story is based on materials provided by University of York. Note: Materials may be edited for content and length.


Journal Reference:

  1. G Vallejo-Fernandez, O Whear, A G Roca, S Hussain, J Timmis, V Patel, K O'Grady. Mechanisms of hyperthermia in magnetic nanoparticles. Journal of Physics D: Applied Physics, 2013; 46 (31): 312001 DOI: 10.1088/0022-3727/46/31/312001

Cite This Page:

University of York. "Physicists offer novel insight into experimental cancer treatment." ScienceDaily. ScienceDaily, 15 July 2013. <www.sciencedaily.com/releases/2013/07/130715070314.htm>.
University of York. (2013, July 15). Physicists offer novel insight into experimental cancer treatment. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2013/07/130715070314.htm
University of York. "Physicists offer novel insight into experimental cancer treatment." ScienceDaily. www.sciencedaily.com/releases/2013/07/130715070314.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) — A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) — Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins