Featured Research

from universities, journals, and other organizations

Clearest new pictures of immune cells

Date:
July 23, 2013
Source:
Manchester University
Summary:
Scientists have revealed new images which provide the clearest picture yet of how white blood immune cells attack viral infections and tumors.

Cluster map.
Credit: Dan Davis University of Manchester

Scientists from The University of Manchester have revealed new images which provide the clearest picture yet of how white blood immune cells attack viral infections and tumours.

Related Articles


They show how the cells, which are responsible for fighting infections and cancer in the human body, change the organisation of their surface molecules, when activated by a type of protein found on viral-infected or tumour cells.

Professor Daniel Davis, who has been leading the investigation into the immune cells, known as natural killers, said the work could provide important clues for tackling disease.

The research reveals the proteins at the surface of immune cells are not evenly spaced but grouped in clusters -- a bit like stars bunched together in galaxies.

Professor Davis, Director of Research at the Manchester Collaborative Centre for Inflammation Research (MCCIR), a partnership between the University and two pharmaceutical companies GlaxoSmithKline and Astra Zeneca, said: "This is the first time scientists have looked at how these immune cells work at such a high resolution. The surprising thing was that these new pictures revealed that immune cell surfaces alter at this scale -- the nano scale -- which could perhaps change their ability to be activated in a subsequent encounter with a diseased cell.

"We have shown that immune cells are not evenly distributed as once thought, but instead they are grouped in very small clumps -- a bit like if you were an astronomer looking at clusters of stars in the Universe and you would notice that they were grouped in clusters. "We studied how these clusters or proteins change when the immune cells are switched on -- to kill diseased cells. Looking at our cells in this much detail gives us a greater understanding about how the immune system works and could provide useful clues for developing drugs to target disease in the future."

Until now the limitations of light microscopy have prevented a clear understanding of how immune cells detect other cells as being diseased or healthy.

The team used high quality, super-resolution fluorescence microscopy to view the cells in blood samples in their laboratory to create the still images published in the journal Science Signalling this week.


Story Source:

The above story is based on materials provided by Manchester University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sophie V. Pageon, Shaun-Paul Cordoba, Dylan M. Owen, Stephen M. Rothery, Anna Oszmiana, Daniel M. Davis. Superresolution Microscopy Reveals Nanometer-Scale Reorganization of Inhibitory Natural Killer Cell Receptors upon Activation of NKG2D. Science Signalling, 23 July 2013 DOI: 10.1126/scisignal.2003947

Cite This Page:

Manchester University. "Clearest new pictures of immune cells." ScienceDaily. ScienceDaily, 23 July 2013. <www.sciencedaily.com/releases/2013/07/130723181128.htm>.
Manchester University. (2013, July 23). Clearest new pictures of immune cells. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2013/07/130723181128.htm
Manchester University. "Clearest new pictures of immune cells." ScienceDaily. www.sciencedaily.com/releases/2013/07/130723181128.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins