Featured Research

from universities, journals, and other organizations

HPV's link to esophageal cancer

Date:
July 24, 2013
Source:
University of New South Wales
Summary:
The human papillomavirus triples the risk of people developing yet another cancer, esophageal squamous cell carcinoma, according to new research.

The human papillomavirus (HPV) triples the risk of people developing yet another cancer, esophageal squamous cell carcinoma (OSCC), according to research led by UNSW academics.

In addition to causing cervical, anal and genital cancers, HPV has more recently been found to cause some head and neck cancers.

"One of the main issues is this form of esophageal cancer is usually diagnosed quite late and so has a very high mortality," says the first author of the paper, Dr Surabhi Liyanage, a PhD candidate with the School of Public Health and Community Medicine, UNSW Medicine.

OSCC is the most common of two types of esophageal cancer. While it is rare in Australia, it is the sixth highest cause of cancer-related deaths world-wide. It is particularly prevalent in China, South Africa and Iran among men in their mid-70s to 80s. It is unknown why the prevalence is so high in those countries, but it is thought to be linked to dietary, lifestyle and environmental factors.

"HPV is another factor which we can add to a long list of causes of OSCC," says Dr Liyanage. "Smoking and alcohol are the main causes, as well as the consumption of extremely hot liquids, lots of red meat and possibly environmental toxins in the diet."

The findings, published today in PLOS ONE, could have implications for vaccination programs around the world.

"This is an important new finding which resolves a previous uncertainty," says senior author, UNSW Professor Raina MacIntyre.

"Given that the most common two cervical cancer-causing HPVs are now preventable by early vaccination, this may be significant in countries where OSCC is frequently found," says Professor MacIntyre, head of the School of Public Health and Community Medicine.

"In China, it is one of the leading causes of cancer death, so Chinese health authorities could consider this in any deliberations they are having about potential benefits of HPV vaccination in their population," she says.

Currently, HPV vaccinations are used most commonly in young people in developed countries to prevent cervical cancer.

"Time will tell whether our universal HPV vaccination program has any additional benefit in prevention of cancers other than cervical cancer," says Professor MacIntyre.

"The findings from this meta-analysis should rekindle the debate about looking at the potential causative role for oncogenic HPVs in esophageal cancer," says another of the authors and a leader in HPV vaccination, Dr Suzanne Garland, from the Royal Women's Hospital in Melbourne.

"These findings will assist the expert group, International Agency for Research on Cancer (IARC), which examines evidence for potential oncogenic roles in various cancers," says Dr Garland. "We look forward to a potential review by IARC of the meta-analysis and other studies in establishing a role or not for HPV."


Story Source:

The above story is based on materials provided by University of New South Wales. Note: Materials may be edited for content and length.


Journal Reference:

  1. Surabhi S. Liyanage, Bayzidur Rahman, Iman Ridda, Anthony T. Newall, Sepehr N. Tabrizi, Suzanne M. Garland, Eva Segelov, Holly Seale, Philip J. Crowe, Aye Moa, C. Raina MacIntyre. The Aetiological Role of Human Papillomavirus in Oesophageal Squamous Cell Carcinoma: A Meta-Analysis. PLoS ONE, 2013; 8 (7): e69238 DOI: 10.1371/journal.pone.0069238

Cite This Page:

University of New South Wales. "HPV's link to esophageal cancer." ScienceDaily. ScienceDaily, 24 July 2013. <www.sciencedaily.com/releases/2013/07/130724200427.htm>.
University of New South Wales. (2013, July 24). HPV's link to esophageal cancer. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/07/130724200427.htm
University of New South Wales. "HPV's link to esophageal cancer." ScienceDaily. www.sciencedaily.com/releases/2013/07/130724200427.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins