Featured Research

from universities, journals, and other organizations

Great-grandmother's cigarette habit could be the cause of child's asthma

Date:
August 5, 2013
Source:
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Summary:
A study finds for the first time that the third generation's asthma may be linked to maternal smoking.

With some 300 million people around the world living with asthma, a study by Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) researchers that was released ahead-of- print found for the first time that maternal smoking can cause the third generation of offspring to suffer from the chronic lung disease.

The study, published online by the American Journal of Physiology -- Lung Cellular and Molecular Physiology, reported that maternal nicotine exposure during pregnancy is linked to asthma in the third generation in disease models. This is known as a "transgenerational" linkage because the third generation was never directly exposed to nicotine or smoking. Previous research had found nicotine exposure was linked to asthma in the second generation, or was a "multigenerational" cause of asthma.

"Even though there are multiple causes for childhood asthma, research linking this serious chronic condition to maternal nicotine exposure during pregnancy for up to three generations should give mothers-to-be even more reasons to reconsider smoking," said Virender K. Rehan, MD, an LA BioMed lead researcher and the corresponding author of the study. "Eliminating the use of tobacco during pregnancy could help halt the rise in childhood asthma and ensure healthier children for generations to come."

Worldwide, approximately 250 million women smoke daily, and the number of people living with asthma is expected to grow by about a third by 2025, reaching approximately 400 million. Twelve percent of women in the U.S. continue to smoke during pregnancy, resulting in the birth of at least 400,000 smoke-exposed infants per year in the U.S. alone.

In previous studies, the researchers have concluded that the cause of the second generation's asthma was epigenetic modification (an environmental factor causing a genetic change). Nicotine was affecting both the lung cells and the sex cells in ways that caused the lungs that developed from those cells to develop abnormally, causing asthma. The current study "paves the way for determining the epigenetic mechanisms" behind smoking and the transmission of asthma to future generations, the researchers concluded.


Story Source:

The above story is based on materials provided by Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed). Note: Materials may be edited for content and length.


Journal Reference:

  1. V. K. Rehan, J. Liu, R. Sakurai, J. S. Torday. Perinatal Nicotine-Induced Transgenerational Asthma. AJP: Lung Cellular and Molecular Physiology, 2013; DOI: 10.1152/ajplung.00078.2013

Cite This Page:

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed). "Great-grandmother's cigarette habit could be the cause of child's asthma." ScienceDaily. ScienceDaily, 5 August 2013. <www.sciencedaily.com/releases/2013/08/130805131009.htm>.
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed). (2013, August 5). Great-grandmother's cigarette habit could be the cause of child's asthma. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/08/130805131009.htm
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed). "Great-grandmother's cigarette habit could be the cause of child's asthma." ScienceDaily. www.sciencedaily.com/releases/2013/08/130805131009.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins