Featured Research

from universities, journals, and other organizations

Breast conserving treatment with radiotherapy reduces risk of local recurrence

Date:
September 18, 2013
Source:
European Organisation for Research and Treatment of Cancer
Summary:
Results of a study shows that breast conserving treatment combined with radiotherapy reduces the risk of local recurrence in women with ductal carcinoma in situ.

Results of EORTC trial 10853 appearing in the Journal of Clinical Oncology show that breast conserving treatment combined with radiotherapy reduces the risk of local recurrence in women with ductal carcinoma in situ (DCIS). The incidence of DCIS has been increasing in the past decades, and this has been attributed to increased detection through breast cancer screening using mammograms. In the EORTC study, adjuvant radiotherapy after local excision reduced the incidence of both in situ and invasive local recurrences by a factor of two and resulted in an overall lower risk of mastectomy.

Related Articles


Following the introduction of radiotherapy combined with breast-conserving surgery for operable invasive breast cancer in the 1980's, several trials were launched to investigate the addition of radiotherapy to local excision of DCIS. These trials showed that radiotherapy reduced both the risk of DCIS and invasive local recurrences. Now the long-term outcomes of local recurrences and survival in women receiving radiotherapy in combination with breast conserving surgery for DCIS have been investigated at a median follow-up of 15.8 years.

Dr. Mila Donker of The Netherlands Cancer Institute, Amsterdam, and lead author of this paper says, "Survival after treatment for DCIS is excellent. Therefore, the question rises whether the current treatment for DCIS (local excision and adjuvant radiotherapy of the breast) is overtreatment. To answer this question, not only long-term data about local disease recurrences and prognosis are important, but also information about the prognosis and treatment in case of recurrence."

Between 1986 and 1996, the phase III EORTC trial 10853 randomized 1010 women with complete local excision of DCIS to no further treatment (503 patients) or radiotherapy (507 patients). The risk of any local recurrence was found to be reduced by 48% (HR: 0.52, 95%CI 0.40-0.68, P<0.001) in the patients who also received radiotherapy. The 15-year local recurrence-free rate was 69% for the group of patients receiving breast conserving surgery alone, but this increased to 82% for the group of patients who also received radiotherapy, and the 15-year invasive local recurrence-free rate was 84% versus 90%, respectively (HR: 0.61, 95%CI 0.42-0.87).

The differences observed in local recurrence did not lead to differences in breast cancer specific survival or overall survival, but patients with invasive local recurrence did have a significantly worse breast cancer specific survival (HR: 17.66, 95%CI 8.86-35.18) as well as overall survival (HR: 5.17, 95%CI 3.09-8.66) than those who did not recur. Thus, an invasive recurrence resulted in a worse prognosis.

A lower overall salvage mastectomy rate after a local recurrence was also observed in the group of patients who also received radiotherapy, 13%, than in those patients who just received breast conserving surgery, 19%. Thus, radiotherapy after breast-conserving surgery for DCIS resulted in an overall lower percentage of patients who were treated with a mastectomy after a local recurrence.

This study highlights the importance of conducting long term follow-up.


Story Source:

The above story is based on materials provided by European Organisation for Research and Treatment of Cancer. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Donker, S. Litiere, G. Werutsky, J.-P. Julien, I. S. Fentiman, R. Agresti, P. Rouanet, C. T. de Lara, H. Bartelink, N. Duez, E. J. T. Rutgers, N. Bijker. Breast-Conserving Treatment With or Without Radiotherapy in Ductal Carcinoma In Situ: 15-Year Recurrence Rates and Outcome After a Recurrence, From the EORTC 10853 Randomized Phase III Trial. Journal of Clinical Oncology, 2013; DOI: 10.1200/JCO.2013.49.5077

Cite This Page:

European Organisation for Research and Treatment of Cancer. "Breast conserving treatment with radiotherapy reduces risk of local recurrence." ScienceDaily. ScienceDaily, 18 September 2013. <www.sciencedaily.com/releases/2013/09/130918101900.htm>.
European Organisation for Research and Treatment of Cancer. (2013, September 18). Breast conserving treatment with radiotherapy reduces risk of local recurrence. ScienceDaily. Retrieved December 26, 2014 from www.sciencedaily.com/releases/2013/09/130918101900.htm
European Organisation for Research and Treatment of Cancer. "Breast conserving treatment with radiotherapy reduces risk of local recurrence." ScienceDaily. www.sciencedaily.com/releases/2013/09/130918101900.htm (accessed December 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Healthier Lifestyles Could Prevent 4 In 10 Cancer Cases

Healthier Lifestyles Could Prevent 4 In 10 Cancer Cases

Newsy (Dec. 26, 2014) If patients had led healthier lifestyles, Cancer Research UK found about 40 percent of cancer cases could have been prevented. Video provided by Newsy
Powered by NewsLook.com
FDA Issues New Warning About Pure Caffeine Powder Usage

FDA Issues New Warning About Pure Caffeine Powder Usage

Newsy (Dec. 24, 2014) The FDA cites two deaths this year linked to pure caffeine powder as warnings of the potentially fatal substance. Video provided by Newsy
Powered by NewsLook.com
Alarming CDC Lab Report Reveals Ebola Sample Mix-Up

Alarming CDC Lab Report Reveals Ebola Sample Mix-Up

Newsy (Dec. 24, 2014) The Centers for Disease Control and Prevention released a report claiming a lab tech in Atlanta might have been exposed to the Ebola virus. Video provided by Newsy
Powered by NewsLook.com
French General Physicians Begin Strike, ER Doctors Back to Work

French General Physicians Begin Strike, ER Doctors Back to Work

AFP (Dec. 23, 2014) French doctors went on strike Tuesday in protest at an upcoming health bill. Emergency room doctors on the other end are returning to work after reaching an historic agreement. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins