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Targeting memory t-cells in type 1 diabetes

Date:
September 22, 2013
Source:
Immune Tolerance Network
Summary:
Encouraging results from the T1DAL study (Targeting effector memory T cells with alefacept in new onset type 1 diabetes) are published today. The T1DAL trial was designed to test whether alefacept would preserve pancreatic beta cell function in newly diagnosed patients. Secondary endpoints including insulin use and rate of hypoglycemic events were lower at 12 months in the alefacept treated group.

Encouraging results from the T1DAL study (Targeting effector memory T cells with alefacept in new onset type 1 diabetes), led by Mark R. Rigby MD, PhD from Indiana University and Riley Hospital for Children in Indianapolis and sponsored by the Immune Tolerance Network (ITN) with additional support from JDRF, are published today in The Lancet Diabetes & Endocrinology.

Alefacept, an engineered fusion protein targeting a surface molecule, CD2, found on T-lymphocytes, was the first biologic therapy approved for moderate to severe plaque psoriasis. By binding CD2, alefacept inhibits co-stimulation and induces T-cell depletion. T-cell mediated destruction of insulin producing pancreatic beta cells is a central feature of Type 1 diabetes, but targeting of CD2 has not previously been evaluated in this disease. The T1DAL trial was designed to test whether alefacept would preserve pancreatic beta cell function in newly diagnosed patients.

The Phase II T1DAL study enrolled 49 new-onset type 1 diabetic subjects, ages 12 to 35, who were randomized into two groups: 33 to alefacept and 16 to placebo. Patients received two twelve week courses (separated by a 12 week pause) of either alefacept or placebo. Twelve months from the start of the study, patients underwent a mixed meal tolerance test to measure the C-peptide response (a measure of insulin production). The primary endpoint, a 2-hour C-peptide response, did not show statistically significant differences between treatment and placebo groups; however, a secondary endpoint, a 4-hour C-peptide response, was significantly higher at 12 months in the treatment group compared to the placebo group. Other secondary endpoints including insulin use and rate of hypoglycemic events were significantly lower at 12 months in the alefacept treated group.

Although the primary endpoint was not met, these encouraging results of key secondary endpoints suggest a disease-modifying effect of alefacept. Additional support for alefacept's therapeutic role comes from analysis of T-cell subtypes of treated patients that showed that effector T cells were primarily targeted while sparing protective regulatory T cells. Lead investigator Dr. Mark Rigby suggests, "The T1DAL study is the first to use an agent to specifically deplete the cells which attack the pancreas in type 1 diabetes, the memory and effector T cells. We also found that regulatory T cells are not depleted with this therapy, suggesting that immune re-education can take place."

Longer 24 month follow-up of the subjects in this study is in progress to evaluate the potential for durable efficacy of the alefacept treatment. "Unfortunately our study was not able to enroll the goal number of participants due to drug availability which prevented more definitive conclusions at this point," said Dr. Rigby. "We are eagerly awaiting additional data over the next year which will help us determine if targeting memory T cells will help those with Type 1 diabetes make insulin for extended periods."


Story Source:

The above story is based on materials provided by Immune Tolerance Network. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark R Rigby, Linda A DiMeglio, Marc S Rendell, Eric I Felner, Jean M Dostou, Stephen E Gitelman, Chetanbabu M Patel, Kurt J Griffin, Eva Tsalikian, Peter A Gottlieb, Carla J Greenbaum, Nicole A Sherry, Wayne V Moore, Roshanak Monzavi, Steven M Willi, Philip Raskin, Antoinette Moran, William E Russell, Ashley Pinckney, Lynette Keyes-Elstein, Michael Howell, Sudeepta Aggarwal, Noha Lim, Deborah Phippard, Gerald T Nepom, James McNamara, Mario R Ehlers. Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial. The Lancet Diabetes & Endocrinology, 2013; DOI: 10.1016/S2213-8587(13)70111-6

Cite This Page:

Immune Tolerance Network. "Targeting memory t-cells in type 1 diabetes." ScienceDaily. ScienceDaily, 22 September 2013. <www.sciencedaily.com/releases/2013/09/130922205910.htm>.
Immune Tolerance Network. (2013, September 22). Targeting memory t-cells in type 1 diabetes. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2013/09/130922205910.htm
Immune Tolerance Network. "Targeting memory t-cells in type 1 diabetes." ScienceDaily. www.sciencedaily.com/releases/2013/09/130922205910.htm (accessed August 21, 2014).

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