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Smoking during pregnancy may increase risk of bipolar disorder in offspring

Date:
October 1, 2013
Source:
Columbia University's Mailman School of Public Health
Summary:
A study published suggests an association between smoking during pregnancy and increased risk for developing bipolar disorder in adult children. Researchers evaluated offspring from a large cohort of pregnant women and found that maternal smoking during pregnancy was associated with a twofold increased risk of bipolar disorder in their offspring.
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Smoking during pregnancy is known to contribute to significant problems in utero and following birth, including low birth weight and attentional difficulties. This is the first study to suggest an association between prenatal tobacco exposure and BD, a serious psychiatric illness marked by significant shifts in mood that alternate between periods of depression and mania. Symptoms typically become noticeable in the late teens or early adulthood.
Credit: © Jasmin Merdan / Fotolia

A study published today in the American Journal of Psychiatry suggests an association between smoking during pregnancy and increased risk for developing bipolar disorder (BD) in adult children. Researchers at the New York State Psychiatric Institute and the Department of Epidemiology at the Mailman School of Public Health at Columbia University, in collaboration with scientists at the Kaiser Permanente Division of Research in Oakland, California, evaluated offspring from a large cohort of pregnant women who participated in the Child Health and Development Study (CHDS) from 1959-1966. The study was based on 79 cases and 654 comparison subjects. Maternal smoking during pregnancy was associated with a twofold increased risk of BD in their offspring.

Smoking during pregnancy is known to contribute to significant problems in utero and following birth, including low birth weight and attentional difficulties. This is the first study to suggest an association between prenatal tobacco exposure and BD, a serious psychiatric illness marked by significant shifts in mood that alternate between periods of depression and mania. Symptoms typically become noticeable in the late teens or early adulthood.

"These findings underscore the value of ongoing public health education on the potentially debilitating, and largely preventable, consequences that smoking may have on children over time," said Alan Brown, MD, MPH, senior author and Professor of Clinical Psychiatry and Epidemiology at the New York State Psychiatric Institute, Columbia University and Mailman School of Public Health.

The authors wrote: "Much of the psychopathology associated with prenatal tobacco exposure clusters around the 'externalizing' spectrum, which includes attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), conduct disorder (CD), and substance abuse disorders. Although not diagnostically classified along the externalizing spectrum, BD shares a number of clinical characteristics with these disorders, including inattention, irritability, loss of self-control, and proclivity to drug/alcohol use." In effect, children who were exposed to tobacco smoke in utero may exhibit some symptoms and behaviors that are found in BD.

A previous study by Dr. Brown and colleagues found that flu virus in pregnant mothers was associated with a fourfold increased risk that their child would develop BD.


Story Source:

The above post is reprinted from materials provided by Columbia University's Mailman School of Public Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ardesheer Talati. Maternal Smoking During Pregnancy and Bipolar Disorder in Offspring. American Journal of Psychiatry, 2013; 170 (10): 1178 DOI: 10.1176/appi.ajp.2013.12121500

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Columbia University's Mailman School of Public Health. "Smoking during pregnancy may increase risk of bipolar disorder in offspring." ScienceDaily. ScienceDaily, 1 October 2013. <www.sciencedaily.com/releases/2013/10/131001192155.htm>.
Columbia University's Mailman School of Public Health. (2013, October 1). Smoking during pregnancy may increase risk of bipolar disorder in offspring. ScienceDaily. Retrieved August 29, 2015 from www.sciencedaily.com/releases/2013/10/131001192155.htm
Columbia University's Mailman School of Public Health. "Smoking during pregnancy may increase risk of bipolar disorder in offspring." ScienceDaily. www.sciencedaily.com/releases/2013/10/131001192155.htm (accessed August 29, 2015).

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