Featured Research

from universities, journals, and other organizations

New method allows quantitative nanoscopic imaging through silicon

Date:
October 2, 2013
Source:
University of Texas at Arlington
Summary:
Scientists have figured out how to quantitatively observe cellular processes taking place on so-called "lab on a chip" devices in a silicon environment. The new technology will be useful in drug development as well as disease diagnosis, researchers say.

A team of scientists from The University of Texas at Arlington and MIT has figured out how to quantitatively observe cellular processes taking place on so-called "lab on a chip" devices in a silicon environment.

Related Articles


The new technology will be useful in drug development as well as disease diagnosis, researchers say.

In a paper published in Nature's online journal Scientific Reports, the team said it overcame past limitations on quantitative microscopy through an opaque media by working with a new combination of near infrared light and a technique called quantitative phase imaging. Quantitative phase imaging is about a decade old. It uses shifts in phases of light, not staining techniques, to aid specimen imaging -- earning the term "label-free."

"To the best of our knowledge, this is the first demonstration of quantitative phase imaging of cellular structure and function in silicon environment," said Assistant Professor of Physics Samarendra Mohanty, head of the Biophysics and Physiology Laboratory at UT Arlington and corresponding author on the paper.

The UT Arlington/MIT team was able to prove success in analyzing specimens through a silicon wafer in two instances. In one, they accomplished full-field imaging of the features of red blood cells to nanometer thickness accuracy. In another, they observed dynamic variation of human embryonic kidney cells in response to change in salt concentration. Mohanty believes that his group's current work on near infrared quantitative phase imaging can lead to non-invasive, label-free monitoring of neuronal activities.

Additional co-authors include: Bipin Joshi and Nelson Cardenas, of UT Arlington; and Ishan Barman, Narahara Chari Dingari, Jaqueline S. Soares and Ramachandra R. Dasari, all of MIT.

"Silicon-based micro devices known as labs-on-a-chip are revolutionizing high throughput analysis of cells and molecules for disease diagnosis and screening of drug effects. However, very little progress has been made in the optical characterization of samples in these systems," said Joshi, a recent graduate and lead author on the paper. "The technology we've developed is well-suited to meet this need."

Barman, now an assistant professor at Johns Hopkins University, said the new paper is a prime example of the type of research he hopes to do -- projects pulled by needs of the biomedical community and continually pushing the edge of biophotonic solutions.

"We envision that this significantly expands the visualization possible in silicon based microelectronic and micromechanical devices," he said.


Story Source:

The above story is based on materials provided by University of Texas at Arlington. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bipin Joshi, Ishan Barman, Narahara Chari Dingari, Nelson Cardenas, Jaqueline S. Soares, Ramachandra R. Dasari, Samarendra Mohanty. Label-free route to rapid, nanoscale characterization of cellular structure and dynamics through opaque media. Scientific Reports, 2013; 3 DOI: 10.1038/srep02822

Cite This Page:

University of Texas at Arlington. "New method allows quantitative nanoscopic imaging through silicon." ScienceDaily. ScienceDaily, 2 October 2013. <www.sciencedaily.com/releases/2013/10/131002112422.htm>.
University of Texas at Arlington. (2013, October 2). New method allows quantitative nanoscopic imaging through silicon. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2013/10/131002112422.htm
University of Texas at Arlington. "New method allows quantitative nanoscopic imaging through silicon." ScienceDaily. www.sciencedaily.com/releases/2013/10/131002112422.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins