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Changes in epigenetic DNA functions links diabetes predisposition to Alzheimer’s disease

Date:
October 23, 2013
Source:
Mount Sinai Medical Center
Summary:
Diabetes and dementia are rising dramatically in the United States and worldwide. In the last few years, epidemiological data has accrued showing that older people with diabetes are significantly more likely to develop cognitive deterioration and increased susceptibility to onset of dementia related to Alzheimer’s disease.

Diabetes and dementia are rising dramatically in the United States and worldwide. In the last few years, epidemiological data has accrued showing that older people with diabetes are significantly more likely to develop cognitive deterioration and increased susceptibility to onset of dementia related to Alzheimer's disease. Now, a research team led by Giulio Maria Pasinetti, MD, PhD, the Saunders Family Chair and Professor of Neurology at the Icahn School of Medicine at Mount Sinai, discovered a novel mechanism through which this may occur. The results are published online Oct. 23, in the journal Diabetes.

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Dr. Pasinetti and colleagues pinpointed changes in post-mortem brains of human subjects. They reported that gene expression was dysfunctional in the brains of diabetic human subjects, and this increase was associated with reduced expression of important molecules that play a critical role in maintaining the structural integrity of brain regions associated with learning.

Excited by this finding, Dr. Pasinetti reasoned that if the hypothesis was correct, similar conditions should be repeated in the laboratory by inducing diabetes in mice genetically predisposed to developing Alzheimer's type memory deterioration. In fact, Dr. Pasinetti's laboratory confirmed this prediction in the mouse model, supporting the hypothesis that diabetes, through epigenetic changes in the brain, may casually promote onset and progression of Alzheimer's disease. Epigenetic changes are chemical changes in DNA that effect gene expression, but don't alter the actual genetic code.

"This new evidence is extremely intriguing, given that approximately 60 percent of Alzheimer's disease patients have at least one serious medical condition associated with diabetes," said Dr. Pasinetti. "What this adds is much needed insight into the potential mechanism that might explain the relationship between diabetes and Alzheimer's disease onset and progression by mechanisms through which DNA functions."

The discovery in Dr. Pasinetti's laboratory has staggering societal implications. More than 5 million are affected by Alzheimer's disease dementia, and the disease incidence is expected to skyrocket in the three decades as the population ages.

"The next question we must ask is how we can translate this into the development of novel disease prevention and treatment strategies," Dr. Pasinetti added. "If we can find out how DNA epigenetic modification can be manipulated pharmacologically, these studies will be instrumental in the formulation of novel treatments and possible preventative strategies in Alzheimer's disease.


Story Source:

The above story is based on materials provided by Mount Sinai Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jun Wang, Bing Gong, Wei Zhao, Cheuk Tang, Merina Varghese, Tuyen Nguyen, Weina Bi, Amanda Bilski, Shimul Begum, Prashant Vempati, Lindsay Knable, Lap Ho, and Giulio M. Pasinetti. Epigenetic mechanisms linking diabetes and synaptic impairments. Diabetes, October 2013

Cite This Page:

Mount Sinai Medical Center. "Changes in epigenetic DNA functions links diabetes predisposition to Alzheimer’s disease." ScienceDaily. ScienceDaily, 23 October 2013. <www.sciencedaily.com/releases/2013/10/131023100953.htm>.
Mount Sinai Medical Center. (2013, October 23). Changes in epigenetic DNA functions links diabetes predisposition to Alzheimer’s disease. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2013/10/131023100953.htm
Mount Sinai Medical Center. "Changes in epigenetic DNA functions links diabetes predisposition to Alzheimer’s disease." ScienceDaily. www.sciencedaily.com/releases/2013/10/131023100953.htm (accessed March 30, 2015).

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