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Preeclampsia during pregnancy may be linked with kidney failure risk

Date:
November 9, 2013
Source:
American Society of Nephrology (ASN)
Summary:
New research suggests that preeclampsia during pregnancy is associated with an increased likelihood of developing kidney failure. However, after adjusting for diabetes and hypertension, the association was attenuated and no longer significant. Additional studies are needed to confirm the association of preeclampsia and kidney failure.
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Preeclampsia during pregnancy may be associated with an increased risk of developing kidney failure, according to a study that will be presented at ASN Kidney Week 2013 November 5¬-10 at the Georgia World Congress Center in Atlanta, GA.

Recent data from registry-based studies suggest that preeclampsia -- a condition in pregnancy characterized by high blood pressure, sometimes with fluid retention and protein excretion in the urine -- is a risk factor for developing kidney failure later in life, but the magnitude of this link and the contributions of individuals' other medical conditions remain unknown. To investigate the issue, researchers led by Andrea Kattah, MD (Mayo Clinic) studied 8362 residents of Olmsted County, MN who gave birth between 1976 and 1982. Kidney failure cases were identified by linkage with the United States Renal Data System; each case was matched to two controls.

A total of 20 cases of kidney failure were identified and available for analysis. The average age at diagnosis of kidney failure was 52.6 years. Per chart review, 8/20 (40%) cases vs 5/40 controls (12.5%) had preeclampsia or eclampsia (which is characterized by convulsions). Diabetes and hypertension were more common in cases than controls (50% vs 15%, 80% vs 45%, respectively).

"Preeclampsia is associated with a higher odds of end stage renal disease. However, after adjusting for diabetes and hypertension, the association was attenuated and no longer significant," according to the investigators. "Larger population-based studies that rely on chart review or prospective studies are needed to confirm the association of preeclampsia and end stage renal disease."


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The above post is reprinted from materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


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American Society of Nephrology (ASN). "Preeclampsia during pregnancy may be linked with kidney failure risk." ScienceDaily. ScienceDaily, 9 November 2013. <www.sciencedaily.com/releases/2013/11/131109192745.htm>.
American Society of Nephrology (ASN). (2013, November 9). Preeclampsia during pregnancy may be linked with kidney failure risk. ScienceDaily. Retrieved August 31, 2015 from www.sciencedaily.com/releases/2013/11/131109192745.htm
American Society of Nephrology (ASN). "Preeclampsia during pregnancy may be linked with kidney failure risk." ScienceDaily. www.sciencedaily.com/releases/2013/11/131109192745.htm (accessed August 31, 2015).

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