Featured Research

from universities, journals, and other organizations

Dual protein knockout could lead to new male contraceptive

Date:
December 3, 2013
Source:
Monash University
Summary:
A new male contraceptive could be on the horizon after scientists identified a novel way to block the transport of sperm during ejaculation.

Pills (stock image). A new male contraceptive could be on the horizon after scientists identified a novel way to block the transport of sperm during ejaculation.
Credit: nmelnychuk / Fotolia

A new male contraceptive could be on the horizon after scientists identified a novel way to block the transport of sperm during ejaculation.

Published today in the journal Proceedings of the National Academy of Science scientists have found that complete male infertility could be achieved by blocking two proteins found on the smooth muscle cells that trigger the transport of sperm.

The researchers demonstrated that the absence of two proteins in mouse models, α1A-adrenoceptor and P2X1-purinoceptor, which mediate sperm transport, caused infertility, without effects on long-term sexual behavior or function.

Lead researchers, Dr Sab Ventura and Dr Carl White of the Monash Institute of Pharmaceutical Sciences, believe the knowledge could be applied to the potential development of a contraceptive pill for men.

"Previous strategies have focused on hormonal targets or mechanisms that produce dysfunctional sperm incapable of fertilization, but they often interfere with male sexual activity and cause long term irreversible effects on fertility," Dr Ventura said.

"We've shown that simultaneously disrupting the two proteins that control the transport of sperm during ejaculation causes complete male infertility, but without affecting the long-term viability of sperm or the sexual or general health of males. The sperm is effectively there but the muscle is just not receiving the chemical message to move it.

Dr Ventura said there was already a drug that targets one of the two proteins, but they would have to find a chemical and develop a drug to block the second one.

"This suggests a therapeutic target for male contraception. The next step is to look at developing an oral male contraceptive drug, which is effective, safe, and readily reversible."

If successful, it is hoped a male contraceptive pill could be available within ten years.

Researchers from University of Melbourne and the University of Leicester, UK, collaborated on the study.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. W. White, Y.-T. Choong, J. L. Short, B. Exintaris, D. T. Malone, A. M. Allen, R. J. Evans, S. Ventura. Male contraception via simultaneous knockout of 1A-adrenoceptors and P2X1-purinoceptors in mice. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1318624110

Cite This Page:

Monash University. "Dual protein knockout could lead to new male contraceptive." ScienceDaily. ScienceDaily, 3 December 2013. <www.sciencedaily.com/releases/2013/12/131203091637.htm>.
Monash University. (2013, December 3). Dual protein knockout could lead to new male contraceptive. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2013/12/131203091637.htm
Monash University. "Dual protein knockout could lead to new male contraceptive." ScienceDaily. www.sciencedaily.com/releases/2013/12/131203091637.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins