Featured Research

from universities, journals, and other organizations

Dual protein knockout could lead to new male contraceptive

Date:
December 3, 2013
Source:
Monash University
Summary:
A new male contraceptive could be on the horizon after scientists identified a novel way to block the transport of sperm during ejaculation.

Pills (stock image). A new male contraceptive could be on the horizon after scientists identified a novel way to block the transport of sperm during ejaculation.
Credit: nmelnychuk / Fotolia

A new male contraceptive could be on the horizon after scientists identified a novel way to block the transport of sperm during ejaculation.

Related Articles


Published today in the journal Proceedings of the National Academy of Science scientists have found that complete male infertility could be achieved by blocking two proteins found on the smooth muscle cells that trigger the transport of sperm.

The researchers demonstrated that the absence of two proteins in mouse models, α1A-adrenoceptor and P2X1-purinoceptor, which mediate sperm transport, caused infertility, without effects on long-term sexual behavior or function.

Lead researchers, Dr Sab Ventura and Dr Carl White of the Monash Institute of Pharmaceutical Sciences, believe the knowledge could be applied to the potential development of a contraceptive pill for men.

"Previous strategies have focused on hormonal targets or mechanisms that produce dysfunctional sperm incapable of fertilization, but they often interfere with male sexual activity and cause long term irreversible effects on fertility," Dr Ventura said.

"We've shown that simultaneously disrupting the two proteins that control the transport of sperm during ejaculation causes complete male infertility, but without affecting the long-term viability of sperm or the sexual or general health of males. The sperm is effectively there but the muscle is just not receiving the chemical message to move it.

Dr Ventura said there was already a drug that targets one of the two proteins, but they would have to find a chemical and develop a drug to block the second one.

"This suggests a therapeutic target for male contraception. The next step is to look at developing an oral male contraceptive drug, which is effective, safe, and readily reversible."

If successful, it is hoped a male contraceptive pill could be available within ten years.

Researchers from University of Melbourne and the University of Leicester, UK, collaborated on the study.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. W. White, Y.-T. Choong, J. L. Short, B. Exintaris, D. T. Malone, A. M. Allen, R. J. Evans, S. Ventura. Male contraception via simultaneous knockout of 1A-adrenoceptors and P2X1-purinoceptors in mice. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1318624110

Cite This Page:

Monash University. "Dual protein knockout could lead to new male contraceptive." ScienceDaily. ScienceDaily, 3 December 2013. <www.sciencedaily.com/releases/2013/12/131203091637.htm>.
Monash University. (2013, December 3). Dual protein knockout could lead to new male contraceptive. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2013/12/131203091637.htm
Monash University. "Dual protein knockout could lead to new male contraceptive." ScienceDaily. www.sciencedaily.com/releases/2013/12/131203091637.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins