Featured Research

from universities, journals, and other organizations

Could a vaccine help ward off MS?

Date:
December 4, 2013
Source:
American Academy of Neurology (AAN)
Summary:
A vaccine used to prevent tuberculosis in other parts of the world may help prevent multiple sclerosis (MS) in people who show the beginning signs of the disease, according to a new study published.

A vaccine used to prevent tuberculosis in other parts of the world may help prevent multiple sclerosis (MS) in people who show the beginning signs of the disease, according to a new study published in the December 4, 2013, online issue of Neurologyฎ, the medical journal of the American Academy of Neurology.

The study involved 73 people who had a first episode that was suggestive of MS, such as numbness, vision problems or problems with balance, and an MRI that showed signs of possible MS. About half of all people in this situation, called clinically isolated syndrome, develop definite MS within two years, while 10 percent have no more MS-related problems.

For the study, 33 of the participants received one injection of a live vaccine called Bacille Calmette-Gu้rin, which is used in other countries to prevent tuberculosis, but is not used for that in the United States. The other participants received a placebo. All of the participants had brain scans once a month for six months. They then received the MS drug interferon beta-1a for a year. After that, they took the MS drug recommended by their neurologist. The development of definite MS was evaluated for five years after the start of the study.

After the first six months, the people who received the vaccine had fewer brain lesions that are signs of MS than those who received the placebo, with three lesions for the vaccinated and seven lesions for the unvaccinated.

By the end of the study, 58 percent of the vaccinated people had not developed MS, compared to 30 percent of those who received the placebo.

There were no major side effects during the study. There was no difference in side effects between those who received the vaccine and those who didn’t.

“These results are promising, but much more research needs to be done to learn more about the safety and long-term effects of this live vaccine,” said study author Giovanni Ristori, MD, PhD, of Sapienza University of Rome in Italy. “Doctors should not start using this vaccine to treat MS or clinically isolated syndrome.”

The results provide support to the “hygiene hypothesis” that better sanitation and use of disinfectants and antibiotics may account for some of the increased rate of MS and other immune system diseases in North America and much of Europe compared with Africa, South America and parts of Asia, according to Dennis Bourdette, MD, of Oregon Health & Science University in Portland and a Fellow of the American Academy of Neurology, who wrote an accompanying editorial. “The theory is that exposure to certain infections early in life might reduce the risk of these diseases by inducing the body to develop a protective immunity.”


Story Source:

The above story is based on materials provided by American Academy of Neurology (AAN). Note: Materials may be edited for content and length.


Journal Reference:

  1. G. Ristori, S. Romano, S. Cannoni, A. Visconti, E. Tinelli, L. Mendozzi, P. Cecconi, R. Lanzillo, M. Quarantelli, C. Buttinelli, C. Gasperini, M. Frontoni, G. Coarelli, D. Caputo, V. Bresciamorra, N. Vanacore, C. Pozzilli, M. Salvetti. Effects of Bacille Calmette-Guerin after the first demyelinating event in the CNS. Neurology, 2013; DOI: 10.1212/01.wnl.0000438216.93319.ab

Cite This Page:

American Academy of Neurology (AAN). "Could a vaccine help ward off MS?." ScienceDaily. ScienceDaily, 4 December 2013. <www.sciencedaily.com/releases/2013/12/131204181242.htm>.
American Academy of Neurology (AAN). (2013, December 4). Could a vaccine help ward off MS?. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2013/12/131204181242.htm
American Academy of Neurology (AAN). "Could a vaccine help ward off MS?." ScienceDaily. www.sciencedaily.com/releases/2013/12/131204181242.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) — The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) — A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins