Featured Research

from universities, journals, and other organizations

Fighting antibiotic-resistant bacteria: Target human cells instead

Date:
December 11, 2013
Source:
American Chemical Society
Summary:
As more reports appear of a grim "post-antibiotic era" ushered in by the rise of drug-resistant bacteria, a new strategy for fighting infection is emerging that targets a patient's cells rather than those of the invading pathogens. The technique interferes with the way that the pathogens take over a patient's cells to cause infection. This approach could help address the world's growing problem of antibiotic-resistant "super bugs."

As more reports appear of a grim "post-antibiotic era" ushered in by the rise of drug-resistant bacteria, a new strategy for fighting infection is emerging that targets a patient's cells rather than those of the invading pathogens. The technique interferes with the way that the pathogens take over a patient's cells to cause infection. This approach, published in the journal ACS Chemical Biology, could help address the world's growing problem of antibiotic-resistant "super bugs."

Huib Ovaa, Jacques Neefjes and colleagues explain that the problem of antibiotic-resistant bacteria poses a major public health threat. Health organizations have warned that unless alternatives to classic antibiotics are developed, even infections from minor scrapes could become deadly. Pharmaceutical companies are working on only a few new antibiotics, and they all take the same approach -- attack the bacteria. But resistance is always a possibility. To get around this, researchers are now looking more closely at how bacteria co-opt the cells they invade for survival. These researchers previously reported that at least one set of host cell proteins, called kinases, can control bacterial growth. Ovaa and Neefjes' team decided to look at another class of proteins, called phosphatases, that act in the opposite way from kinases to see if inhibiting them would have a similar effect.

In lab tests, they identified phosphatases in human cells that are involved in bacterial survival. They also identified small molecules, or potential drugs, that could stop those phosphatases from working. Those molecules, which could form a new class of antibiotics, successfully stopped Salmonella, their test bacteria, from growing. Because this approach jams the host cell machinery rather than directly attacking the bacteria, the chances of bacteria developing resistance could be very low, say the researchers. They also say that the research shows that phosphatases, like kinases, could be general targets for drug development.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Harald M. H. G. Albers, Coenraad Kuijl, Jeroen Bakker, Loes Hendrickx, Sharida Wekker, Nadha Farhou, Nora Liu, Bernat Blasco-Moreno, Tiziana Scanu, Jeroen den Hertog, Patrick Celie, Huib Ovaa, Jacques Neefjes. Integrating Chemical and Genetic Silencing Strategies To Identify Host Kinase-Phosphatase Inhibitor Networks That Control Bacterial Infection. ACS Chemical Biology, 2013; 131125093526007 DOI: 10.1021/cb400421a

Cite This Page:

American Chemical Society. "Fighting antibiotic-resistant bacteria: Target human cells instead." ScienceDaily. ScienceDaily, 11 December 2013. <www.sciencedaily.com/releases/2013/12/131211131822.htm>.
American Chemical Society. (2013, December 11). Fighting antibiotic-resistant bacteria: Target human cells instead. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2013/12/131211131822.htm
American Chemical Society. "Fighting antibiotic-resistant bacteria: Target human cells instead." ScienceDaily. www.sciencedaily.com/releases/2013/12/131211131822.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins