Featured Research

from universities, journals, and other organizations

Investigators identify first biomarker linked to delirium duration

Date:
December 16, 2013
Source:
Indiana University
Summary:
Researchers have identified the first biomarker that appears to be linked to the duration of delirium. This novel role for S100 as a biomarker for delirium duration in critically ill patients may have important implications for refining future delirium treatment in intensive care unit patients.

Researchers from the Regenstrief Institute and the Indiana University Center for Aging Research have identified the first biomarker that appears to be linked to the duration of delirium. This novel role for S100 as a biomarker for delirium duration in critically ill patients may have important implications for refining future delirium treatment in intensive care unit patients.

Delirium in older adults is associated with increased probability of developing dementia and to a high death rate. Duration of delirium in the ICU has been identified as an independent predictor of mortality.

S100β, or S100 calcium binding protein B, has previously been identified as a marker associated with delirium, but this is the first study to link it to the duration of delirium in critically ill patients. It is estimated that each year more than 7 million hospitalized Americans suffer from the acute confusion and disorientation characteristic of delirium and about half of mechanically ventilated patients in the ICU develop delirium.

The study, published online this month in the peer reviewed open access International Journal of General Medicine, found that ICU patients with abnormally elevated levels of S100β either on day 1 or day 8, or both, had higher delirium duration compared to patients with normal S100β levels on both days.

"Using the biomarker to identify patients with a predisposition toward longer delirium duration should be useful in instituting more effective and personalized clinical therapies, with the end goal of decreasing the burden of delirium for both the patient and the health care system," said Regenstrief Institute investigator and IU Center for Aging Research scientist Babar Ali Khan, M.D., who led the study.

"Utilizing a simple blood test presents an easy and real opportunity to decrease the burden of the syndrome and thereby diminish progression to cognitive impairment in older adults," he said. "Since every day with delirium in the ICU is associated with a 10 percent increased likelihood of death, it's critical to diminish its duration and ultimately prevent it."

Adjusting for age, gender, race and other medical conditions, hospitalized patients with delirium have stays that are more than twice as long; have a greater probability of being discharged to a long-term-care facility; and have a much higher probability of developing dementia than patients who do not experience delirium, according to the American Delirium Society.

Strategies to prevent delirium or decrease delirium duration include waking and conducting "breathing drills" for ventilated patients as well as promoting early mobility and exercise while in the ICU, according to Dr. Khan, a pulmonologist and ICU physician who is an assistant professor of medicine at the IU School of Medicine and medical director of the Eskenazi Health Critical Care Recovery Center.

The research more clearly establishes the S-100 biomarker as an index of the duration of delirium and suggests one possible mechanism that leads to higher delirium duration. It is thought that the biomarker reflects the degree of injury to non-neuronal support (i.e., glial) cells in the brain caused by inflammation, and specifically indexes the activation of glial cells called astrocytes.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Babar A Khan, Mark O Farber, Noll Campbell, Anthony Perkins, Nagendra Prasad, Siu Hui, Douglas Miller, Enrique Calvo-Ayala, Ruxandra Corina Ionescu, Anantha Shekhar, E. Wesley Ely, Malaz Boustani, John Buckley. S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit – an exploratory analysis. International Journal of General Medicine, 2013; 855 DOI: 10.2147/IJGM.S51004

Cite This Page:

Indiana University. "Investigators identify first biomarker linked to delirium duration." ScienceDaily. ScienceDaily, 16 December 2013. <www.sciencedaily.com/releases/2013/12/131216142420.htm>.
Indiana University. (2013, December 16). Investigators identify first biomarker linked to delirium duration. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2013/12/131216142420.htm
Indiana University. "Investigators identify first biomarker linked to delirium duration." ScienceDaily. www.sciencedaily.com/releases/2013/12/131216142420.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins