Featured Research

from universities, journals, and other organizations

Researchers discover mechanism controlling development of myelodysplastic syndromes

Date:
December 17, 2013
Source:
Moffitt Cancer Center
Summary:
Researchers have discovered a control mechanism that can trigger the development of myelodysplastic syndromes (MDS), a group of blood cancers. This finding may lead to therapies capable of preventing the progression of these diseases.

Researchers at the Moffitt Cancer Center have discovered a control mechanism that can trigger the development of myelodysplastic syndromes (MDS), a group of blood cancers. This finding may lead to therapies capable of preventing the progression of these diseases.

MDS primarily affects older individuals, with approximately 12,000 new cases diagnosed each year. In MDS, a person's blood is not able to make one or more types of healthy blood cells -- red blood cells, white blood cells or platelets. Instead, the patient has a high number of immature stem cells that do not develop properly. This can lead to anemia and a higher risk of infection and bleeding. MDS patients also have an increased risk of developing leukemia. Unfortunately, there is no effective therapy for MDS and scientists do not have a clear answer on how MDS develops.

In their translational study, Moffitt clinical and basic science researchers found that MDS patients have a higher number of suppressor cells in their bone marrow. These suppressor cells promote inflammation and prevent blood stem cells from developing properly. Inflammation is known to be involved in the development of different types of cancer.

"We discovered that two different molecules, S100A9 and CD33, in the myeloid-derived suppressor cells bound to one another to promote inflammation leading to the development of MDS," said Sheng Wei, M.D., associate member of Moffitt's Immunology Program.

These researchers created a mouse model of human MDS based on their discovery. They used the model to show that by targeting the myeloid-derived suppressor cells and blocking the CD33 molecule's ability to communicate, blood cells were able to develop normally.

"Our findings suggests small molecular drugs targeting the S100A9 and CD33 molecule's signaling pathways can be developed to make myeloid-derived suppressor cells inactive," noted Wei. "Now we are collaborating with a pharmaceutical company to develop a phase I trial targeting this pathway on humanized monoclonal antibodies, which are mice antibodies that have been modified to be similar to human antibodies."

The researcher added that the results from this study may have an impact on more than just MDS patients because higher levels of myeloid-derived suppressor cells are found with several other types of cancer.

The study appeared in the Nov. issue of the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Moffitt Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xianghong Chen, Erika A. Eksioglu, Junmin Zhou, Ling Zhang, Julie Djeu, Nicole Fortenbery, Pearlie Epling-Burnette, Sandra Van Bijnen, Harry Dolstra, John Cannon, Je-in Youn, Sarah S. Donatelli, Dahui Qin, Theo De Witte, Jianguo Tao, Huaquan Wang, Pingyan Cheng, Dmitry I. Gabrilovich, Alan List, Sheng Wei. Induction of myelodysplasia by myeloid-derived suppressor cells. Journal of Clinical Investigation, 2013; 123 (11): 4595 DOI: 10.1172/JCI67580

Cite This Page:

Moffitt Cancer Center. "Researchers discover mechanism controlling development of myelodysplastic syndromes." ScienceDaily. ScienceDaily, 17 December 2013. <www.sciencedaily.com/releases/2013/12/131217123803.htm>.
Moffitt Cancer Center. (2013, December 17). Researchers discover mechanism controlling development of myelodysplastic syndromes. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/12/131217123803.htm
Moffitt Cancer Center. "Researchers discover mechanism controlling development of myelodysplastic syndromes." ScienceDaily. www.sciencedaily.com/releases/2013/12/131217123803.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins