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Scientists find groovy way to influence specialization of stem cells

Date:
December 18, 2013
Source:
Queen Mary, University of London
Summary:
Researchers have shown, for the first time, that the specialized role stem cells go on to perform is controlled by primary cilia -- tiny hair-like structures protruding from a cell.

The primary cilia were grown on micro-grooves 10 micrometres in size.
Credit: Queen Mary, University of London

Stem cells are capable of becoming any cell type within the body through the process of differentiation.

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The discovery has the potential for application in the development of new therapies for a range of medical treatments where scientists aim to replace or regenerate tissues that have become diseased or dysfunctional.

Publishing in the journal Scientific Reports, the researchers found that growing adult stem cells on micro-grooved surfaces disrupts the biochemical pathway that determines the length of the primary cilia. This change in length of the structure ultimately controls the subsequent behaviour of the stem cells.

"Primary cilia are a thousand times smaller than the width of a human hair and are a ubiquitous feature of most cell types but were once thought to be irrelevant. However, our research shows that they play a key role in stem cell differentiation," explains co-author Professor Martin Knight from Queen Mary's School of Engineering and Materials Science and the Institute of Bioengineering.

"We found it's possible to control stem cell specialization by manipulating primary cilia elongation, and that this occurs when stem cells are grown on these special grooved surfaces."

Stem cells are being considered to treat a number of degenerative conditions such as arthritis, Alzheimer's disease and Parkinson's disease.


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Martin Knight et al. Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells. Scientific Reports, December 2013

Cite This Page:

Queen Mary, University of London. "Scientists find groovy way to influence specialization of stem cells." ScienceDaily. ScienceDaily, 18 December 2013. <www.sciencedaily.com/releases/2013/12/131218100131.htm>.
Queen Mary, University of London. (2013, December 18). Scientists find groovy way to influence specialization of stem cells. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2013/12/131218100131.htm
Queen Mary, University of London. "Scientists find groovy way to influence specialization of stem cells." ScienceDaily. www.sciencedaily.com/releases/2013/12/131218100131.htm (accessed March 1, 2015).

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