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Targeting certain kidney cells may help treat kidney failure

Date:
January 9, 2014
Source:
American Society of Nephrology (ASN)
Summary:
Putative kidney progenitor cells contribute to kidney function decline by causing kidney scarring. Targeting these cells may therefore help prevent or treat kidney failure. Researchers have identified an additional but limited reserve of kidney filtering cells that are present at birth and become mature and functional filter cells by adulthood.
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FULL STORY

New research reveals that certain cells contribute to kidney function decline, making them attractive targets for treatments against kidney failure. The findings will appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

The blood-filtering cells in the kidneys -- called podocytes -- are critical to kidney function, and kidney failure can occur when as little as about 20% to 30% of them are lost. Marcus Moeller, MD, Bart Smeets, PhD, Katja Berger (RWTH University of Aachen, in Germany), and their colleagues looked to see if they could coax podocytes to be generated from putative kidney progenitor cells -- termed parietal cells -- as a potential treatment strategy for kidney failure.

Through experiments conducted in mice, the researchers found that podocytes cannot be renewed from parietal cells. In fact, after the loss of podocytes, parietal cells play a negative role by causing kidney scarring that contributes to progressive kidney function decline. "This opens a very important new strategy to prevent loss of kidney function: by inhibiting the parietal cells from doing their destructive work," said Dr. Moeller.

The researchers did, however, detect an additional but limited reserve of podocytes that are present at birth and become mature and functional filter cells by adulthood.

"Our results indicate that research efforts should be directed towards preserving our limited pool of filter cells and to develop pharmacological strategies to inhibit scarring of the kidney by parietal cells," said Dr. Moeller.


Story Source:

The above post is reprinted from materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. Marcus Moeller, MD, Bart Smeets, PhD, Katja Berger, Kevin Schulte, MD, Peter Boor, MD, Christoph Kuppe, MD, Toin van Kuppevelt, MD, and Jürgen Floege, MD. The Regenerative Potential of Parietal Epithelial Cells in Adult Mice. Journal of the American Society of Nephrology, January 2014

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American Society of Nephrology (ASN). "Targeting certain kidney cells may help treat kidney failure." ScienceDaily. ScienceDaily, 9 January 2014. <www.sciencedaily.com/releases/2014/01/140109175447.htm>.
American Society of Nephrology (ASN). (2014, January 9). Targeting certain kidney cells may help treat kidney failure. ScienceDaily. Retrieved July 7, 2015 from www.sciencedaily.com/releases/2014/01/140109175447.htm
American Society of Nephrology (ASN). "Targeting certain kidney cells may help treat kidney failure." ScienceDaily. www.sciencedaily.com/releases/2014/01/140109175447.htm (accessed July 7, 2015).

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