Featured Research

from universities, journals, and other organizations

Targeting certain kidney cells may help treat kidney failure

Date:
January 9, 2014
Source:
American Society of Nephrology (ASN)
Summary:
Putative kidney progenitor cells contribute to kidney function decline by causing kidney scarring. Targeting these cells may therefore help prevent or treat kidney failure. Researchers have identified an additional but limited reserve of kidney filtering cells that are present at birth and become mature and functional filter cells by adulthood.

New research reveals that certain cells contribute to kidney function decline, making them attractive targets for treatments against kidney failure. The findings will appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

The blood-filtering cells in the kidneys -- called podocytes -- are critical to kidney function, and kidney failure can occur when as little as about 20% to 30% of them are lost. Marcus Moeller, MD, Bart Smeets, PhD, Katja Berger (RWTH University of Aachen, in Germany), and their colleagues looked to see if they could coax podocytes to be generated from putative kidney progenitor cells -- termed parietal cells -- as a potential treatment strategy for kidney failure.

Through experiments conducted in mice, the researchers found that podocytes cannot be renewed from parietal cells. In fact, after the loss of podocytes, parietal cells play a negative role by causing kidney scarring that contributes to progressive kidney function decline. "This opens a very important new strategy to prevent loss of kidney function: by inhibiting the parietal cells from doing their destructive work," said Dr. Moeller.

The researchers did, however, detect an additional but limited reserve of podocytes that are present at birth and become mature and functional filter cells by adulthood.

"Our results indicate that research efforts should be directed towards preserving our limited pool of filter cells and to develop pharmacological strategies to inhibit scarring of the kidney by parietal cells," said Dr. Moeller.


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. Marcus Moeller, MD, Bart Smeets, PhD, Katja Berger, Kevin Schulte, MD, Peter Boor, MD, Christoph Kuppe, MD, Toin van Kuppevelt, MD, and Jόrgen Floege, MD. The Regenerative Potential of Parietal Epithelial Cells in Adult Mice. Journal of the American Society of Nephrology, January 2014

Cite This Page:

American Society of Nephrology (ASN). "Targeting certain kidney cells may help treat kidney failure." ScienceDaily. ScienceDaily, 9 January 2014. <www.sciencedaily.com/releases/2014/01/140109175447.htm>.
American Society of Nephrology (ASN). (2014, January 9). Targeting certain kidney cells may help treat kidney failure. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2014/01/140109175447.htm
American Society of Nephrology (ASN). "Targeting certain kidney cells may help treat kidney failure." ScienceDaily. www.sciencedaily.com/releases/2014/01/140109175447.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) — Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins