Featured Research

from universities, journals, and other organizations

Cognitive therapy 'safe and acceptable' to treat schizophrenia, study finds

Date:
February 5, 2014
Source:
Manchester University
Summary:
Researchers have shown cognitive therapy can be used as a safe and acceptable alternative treatment to for people with schizophrenia spectrum disorders who have chosen not to take antipsychotic drugs. Antipsychotic drugs are usually the first line of treatment for schizophrenia; however, many patients refuse or discontinue their pharmacological treatment. Research now shows cognitive therapy significantly reduced psychiatric symptoms in patients not taking antipsychotic drugs.

Researchers from The University of Manchester have shown cognitive therapy can be used as a safe and acceptable alternative treatment to for people with schizophrenia spectrum disorders who have chosen not to take antipsychotic drugs.

Antipsychotic drugs are usually the first line of treatment for schizophrenia; however, many patients refuse or discontinue their pharmacological treatment.

Research published in The Lancet shows cognitive therapy significantly reduced psychiatric symptoms in patients not taking antipsychotic drugs.

The study, funded by the National Institute for Health Research, aimed to establish whether cognitive therapy was effective in reducing psychiatric symptoms in people with schizophrenia spectrum disorders who had chosen not to take antipsychotic drugs.

Researchers randomly selected 74 patients aged 16-65 years with schizophrenia spectrum disorders who had chosen not to take antipsychotic drugs for psychosis at two UK centres between February 2010 and May 2013. The patients were randomly assigned to receive two types of treatment. 37 received cognitive therapy plus treatment as usual and 37 received treatment as usual.

The researchers then looked at each patient's total score on the positive and negative syndrome scale (PANSS). This was assessed at the start of the treatment and at months 3, 6, 9, 12, 15, and 18.

There were eight serious adverse events: two in patients in the cognitive therapy group (one attempted overdose and one patient presenting risk to others, both after therapy), and six in those in the treatment as usual group (two deaths, both of which were deemed unrelated to trial participation or mental health; three compulsory admissions to hospital for treatment under the mental health act; and one attempted overdose).

Overall the researchers found cognitive therapy significantly reduced psychiatric symptoms and seems to be a safe and acceptable alternative for people with schizophrenia spectrum disorders who have chosen not to take antipsychotic drugs.

Professor Anthony Morrison, from the School of Psychological Sciences based at The University of Manchester, said: "Our evidence suggests cognitive treatments do benefit patients with schizophrenia spectrum disorders who have chosen not to take antipsychotic drugs but a larger, definitive trial is now needed."

Writing in a linked Comment in The Lancet, Oliver Howes from the Clinical Sciences Centres and Institute of Psychiatry, London, said: "Morrison and colleagues' findings provide proof of concept that cognitive therapy is an alternative to antipsychotic treatment. Clearly this outcome will need further testing, but, if further work supports the relative effectiveness of cognitive therapy, a comparison between such therapy and antipsychotic treatment will be needed to inform patient choice. If positive, findings from such a comparison would be a step change in the treatment of schizophrenia, providing patients with a viable alternative to antipsychotic treatment for the first time, something that is sorely needed."

Professor Morrison and colleagues are about to commence such a study in Manchester to compare cognitive therapy alone with antipsychotic medication alone and with a combined treatment in people with schizophrenia spectrum disorders.


Story Source:

The above story is based on materials provided by Manchester University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anthony P Morrison, Douglas Turkington, Melissa Pyle, Helen Spencer, Alison Brabban, Graham Dunn, Tom Christodoulides, Rob Dudley, Nicola Chapman, Pauline Callcott, Tim Grace, Victoria Lumley, Laura Drage, Sarah Tully, Kerry Irving, Anna Cummings, Rory Byrne, Linda M Davies, Paul Hutton. Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial. The Lancet, 2014; DOI: 10.1016/S0140-6736(13)62246-1

Cite This Page:

Manchester University. "Cognitive therapy 'safe and acceptable' to treat schizophrenia, study finds." ScienceDaily. ScienceDaily, 5 February 2014. <www.sciencedaily.com/releases/2014/02/140205210413.htm>.
Manchester University. (2014, February 5). Cognitive therapy 'safe and acceptable' to treat schizophrenia, study finds. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2014/02/140205210413.htm
Manchester University. "Cognitive therapy 'safe and acceptable' to treat schizophrenia, study finds." ScienceDaily. www.sciencedaily.com/releases/2014/02/140205210413.htm (accessed April 16, 2014).

Share This



More Mind & Brain News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
App Fights Jet Lag With The Power Of Math

App Fights Jet Lag With The Power Of Math

Newsy (Apr. 13, 2014) Researchers at the University of Michigan have designed an app to fight jet lag by adjusting your body's light intake. Video provided by Newsy
Powered by NewsLook.com
Treatment Gaps Endangering Cops, Mentally Ill

Treatment Gaps Endangering Cops, Mentally Ill

AP (Apr. 10, 2014) As states slash funding for mental health services, police officers are interacting more than ever with people suffering from schizophrenia and other serious disorders of the mind. The consequences can be deadly. (April 10) Video provided by AP
Powered by NewsLook.com
Teen Drinking Rates Linked To Alcohol Mentions In Pop Music

Teen Drinking Rates Linked To Alcohol Mentions In Pop Music

Newsy (Apr. 9, 2014) A University of Pittsburgh study found pop music that mentions alcohol is linked to higher drinking rates among teens. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins