Featured Research

from universities, journals, and other organizations

Sticky nanoparticles developed to fight heart disease

Date:
February 18, 2014
Source:
Clemson University
Summary:
Nanoparticles that can deliver drugs targeting damaged arteries have been developed as a non-invasive method to fight heart disease. Heart disease is the leading cause of death in the U.S., according to the Centers for Disease Control and Prevention. One of the standard ways to treat clogged and damaged arteries currently is to implant vascular stents, which hold the vessels open and release such drugs as paclitaxel. The researchers of this new study hope their advanced nanoparticles could be used alongside stents or in lieu of them.

Clemson University researchers have developed nanoparticles that can deliver drugs targeting damaged arteries, a non-invasive method to fight heart disease. Heart disease is the leading cause of death in the U.S., according to the Centers for Disease Control and Prevention. One of the standard ways to treat clogged and damaged arteries currently is to implant vascular stents, which hold the vessels open and release such drugs as paclitaxel.

Related Articles


The researchers, led by Clemson bioengineering professor Naren Vyavahare, hope their advanced nanoparticles could be used alongside stents or in lieu of them.

"Healthy arteries have elastic fibers that provide elasticity. They are like rubber bands in the tissue that allow expansion and recoil during blood flow," Vyavahare said. "In most cardiovascular diseases, elastic fibers in arteries get damaged, creating hooks that can be used to target drugs."

The nanoparticles, coated with a sticky protein, latch onto damaged arteries and can deliver a drug to the site in slow release fashion. These nanoparticles can be engineered to deliver an array of drugs to the damaged or clogged artery, a common example being paclitaxel, which inhibits cell division and helps prevent growth of scar tissue that can clog arteries. These particles also have unique surfaces that allow prolonged circulation time, providing more opportunities for these particles to accumulate at the damage site.

"We developed nanoparticles that have antibodies on the surface that attach to diseased sites like Velcro," said Vyavahare. "Interestingly, these newly created nanoparticles only accumulate at the damaged artery, not in the healthy arteries, enabling site-specific drug delivery."

"These nanoparticles can be delivered intravenously to target injured areas and can administer drugs over longer periods of time, thus avoiding repeated surgical interventions at the disease site," said Aditi Sinha, a Clemson graduate student and lead author on a paper soon to be published in journal Nanomedicine: Nanotechnolgy, Biology and Medicine.

The work is a promising step toward new treatments for cardiovascular and other diseases. The research team is testing the nanoparticles to determine the most effective drug dosage for vascular tissue repair. This technology can have variety of applications in other diseases, such as chronic obstructive pulmonary disease, Marfan syndrome and elastic fiber-related disorders, such as aortic aneurysms.


Story Source:

The above story is based on materials provided by Clemson University. Note: Materials may be edited for content and length.


Cite This Page:

Clemson University. "Sticky nanoparticles developed to fight heart disease." ScienceDaily. ScienceDaily, 18 February 2014. <www.sciencedaily.com/releases/2014/02/140218110750.htm>.
Clemson University. (2014, February 18). Sticky nanoparticles developed to fight heart disease. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2014/02/140218110750.htm
Clemson University. "Sticky nanoparticles developed to fight heart disease." ScienceDaily. www.sciencedaily.com/releases/2014/02/140218110750.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins