Featured Research

from universities, journals, and other organizations

Repeat emergency visits for opioid overdose raise risk of hospitalization, respiratory failure

Date:
March 11, 2014
Source:
Massachusetts General Hospital
Summary:
Patients brought to hospital emergency departments more than once in a year for treatment of opioid drug overdoses are more likely to be hospitalized for overdose and to need respiratory support with a mechanical ventilator. The authors note that the increased use of opioid drugs for pain management -- reflected in a quadrupling in sales between 1999 and 2010 -- has been accompanied by a rising incidence of opioid overdoses, leading to an 183 percent increase in ED visits for such overdoses nationwide from 2004 to 2011.

Patients brought to hospital emergency departments (EDs) more than once in a year for treatment of opioid drug overdoses are more likely to be hospitalized for overdose and to need respiratory support with a mechanical ventilator. A study conducted by Massachusetts General Hospital (MGH) investigators also identified factors that increased the risk of subsequent overdoses requiring emergency department visits.

"To our knowledge this is the first study that has identified risk factors for repeat ED visits for opioid overdose," says Kohei Hasegawa, MD, MPH, MGH Department of Emergency Medicine, lead author of the report to be published in the April issue of Mayo Clinic Proceedings. "The dilemma of treating pain appropriately while avoiding opioid-associated adverse events is complicated by insufficient data on those risk factors, and better understanding will help us develop more targeted preventive care."

The authors note that the increased use of opioid drugs for pain management -- reflected in a quadrupling in sales between 1999 and 2010 -- has been accompanied by a rising incidence of opioid overdoses, leading to an 183 percent increase in ED visits for such overdoses nationwide from 2004 to 2011. Previous studies of overdose risk factors have examined limited populations, and their lack of information on factors associated with subsequent hospitalizations and near-fatal events -- defined as the use of mechanical ventilation to support respiratory function -- could impede efforts to balance the use of opioids for pain management with the avoidance of overdoses and other adverse events.

The current study was designed to better define the impact of ED visits for opioid overdoses, with a focus on those with more than one overdose in a year, and to determine whether frequent overdose visits were associated with more hospital admissions, near-fatal events and deaths. The investigators analyzed information from state databases covering ED visits and inpatient admissions in Florida and California during 2010 and 2011. They identified almost 20,000 adults who were admitted at least once in 2010 for overdose of any opioids, including both prescription pain medications and illegal drugs like heroin. Almost 1,400 -- 7 percent of the total -- had two or more ED visits for overdose during the year following the first, with some having as many as five; and those individuals accounted for 15 percent of all overdose visits.

Analysis of potential risk factors identified several that were associated with repeat visits for overdoses -- including low income, public insurance through Medicare or Medicaid, and additional health conditions such as alcohol or drug dependence, psychiatric or neurological illness, and chronic pulmonary disease. Also associated with an increased risk were being middle aged, white and male. While around half of patients with any ED visits for opioid overdose were hospitalized, those with frequent visits were more likely to be admitted.

About one tenth of all overdose visits involved ventilator-requiring non-fatal events -- again with a greater incidence among those with frequent visits -- and the overall death rate was 1 percent. Analysis of hospital charges associated with opioid overdose ED visits -- available only for Florida -- revealed total costs of $208 million during the one-year follow-up period, with 92 percent of those charges resulting from patients who had more than one hospitalization

"Every incidence of opioid overdose is theoretically preventable, and our findings underscore the importance of integrated and multifaceted strategies to reduce overdoses and the resulting use of health care services," says Hasegawa, an assistant professor of Surgery at Harvard Medical School. "Our understanding of characteristics that increase the risks associated with the use of opioid pain medications is still limited, so future studies to better define those risks and develop targeted, prevention-oriented care will be essential to improving the care of patients taking these powerful drugs that can be so important for their quality of life."


Story Source:

The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts General Hospital. "Repeat emergency visits for opioid overdose raise risk of hospitalization, respiratory failure." ScienceDaily. ScienceDaily, 11 March 2014. <www.sciencedaily.com/releases/2014/03/140311124158.htm>.
Massachusetts General Hospital. (2014, March 11). Repeat emergency visits for opioid overdose raise risk of hospitalization, respiratory failure. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2014/03/140311124158.htm
Massachusetts General Hospital. "Repeat emergency visits for opioid overdose raise risk of hospitalization, respiratory failure." ScienceDaily. www.sciencedaily.com/releases/2014/03/140311124158.htm (accessed October 2, 2014).

Share This



More Mind & Brain News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Stopping School Violence

Stopping School Violence

Ivanhoe (Oct. 1, 2014) A trauma doctor steps out of the hospital and into the classroom to teach kids how to calmly solve conflicts, avoiding a trip to the ER. Video provided by Ivanhoe
Powered by NewsLook.com
Pineal Cysts: Debilitating Pain

Pineal Cysts: Debilitating Pain

Ivanhoe (Oct. 1, 2014) A tiny cyst in the brain that can cause debilitating symptoms like chronic headaches and insomnia, and the doctor who performs the delicate surgery to remove them. Video provided by Ivanhoe
Powered by NewsLook.com
Burning Away Brain Tumors

Burning Away Brain Tumors

Ivanhoe (Oct. 1, 2014) Doctors are 'cooking' brain tumors. Hear how this new laser-heat procedure cuts down on recovery time. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins