Featured Research

from universities, journals, and other organizations

Purified fish oils could help treat rare disease affecting newborn babies

Date:
March 13, 2014
Source:
University of Manchester
Summary:
A rare and potentially lethal disease of newborn babies whose bodies make too much insulin may be treatable with fish oils, according to researchers. The disease, called congenital hyperinsulinism, means that the infant's brain is starved of blood sugar which can lead to brain damage or long-term disability. But by giving the children purified fish oils similar to those used to treat some heart attack patients, alongside standard medical treatment, their blood sugar levels improve, the researchers have reported.

A rare and potentially lethal disease of newborn babies whose bodies make too much insulin may be treatable with fish oils, according to researchers from The University of Manchester.

The disease, called congenital hyperinsulinism, means that the infant's brain is starved of blood sugar which can lead to brain damage or long-term disability. But by giving the children purified fish oils similar to those used to treat some heart attack patients, alongside standard medical treatment, their blood sugar levels improve, the researchers reported today in the open-access journal Frontiers in Endocrinology.

Congenital hyperinsulinism -- the clinical opposite of diabetes -- is a rare disorder affecting roughly 1 in 50,000 children overall in the UK. It causes the child's body to produce too much insulin, leading to frequent low blood sugar episodes.

Low blood sugar in the baby's developing brain can lead to long term disabilities or brain damage, according to previous research carried out by the team.

Dr Karen Cosgrove, from the University's Faculty of Life Sciences who helped to carry out the new study, says: "Although we didn't see enormous changes in our patients during the research, the effects were small but positive. It is important for all babies with congenital hyperinsulinism because it is a condition which is so difficult to treat."

Researchers from The University of Manchester along with consultants from the Royal Manchester Children's Hospital part of Central Manchester University Hospitals NHS Foundation Trust, teamed up for the research. Royal Manchester Children's Hospital is the base for the Northern Congenital Hyperinsulinism (NorCHI) service which is a highly specialised service for the treatment of this condition.

"Our findings are paving the way for further research into how newer treatments can help to stabilise blood sugar levels in babies with congenital hyperinsulinism" says Dr Mars Skae, Consultant in Paediatric Endocrinology at Royal Manchester Children's Hospital -- and key member of the NorCHI team.

"The current medical treatment for children with congenital hyperinsulinism has been quite limited. The addition of this fish oil supplement may be a simple but effective way of treating low blood sugars in many children with this difficult condition" says Doctor Indi Banerjee, Consultant in Paediatric Endocrinology at Royal Manchester Children's Hospital and clinical lead for NORCHI.


Story Source:

The above story is based on materials provided by University of Manchester. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mars Skae, Hima Bindu Avatapalle, Indraneel Banerjee, Lindsey Rigby, Andy Vail, Peter Foster, Christiana Charalambous, Louise Bowden, Raja Padidela, Leena Patel, Sarah Ehtisham, Karen E. Cosgrove, Mark J. Dunne, Peter E. Clayton. Reduced Glycemic Variability in Diazoxide-Responsive Children with Congenital Hyperinsulinism Using Supplemental Omega-3-Polyunsaturated Fatty Acids; A Pilot Trial with MaxEPAR. Frontiers in Endocrinology, 2014; 5 DOI: 10.3389/fendo.2014.00031

Cite This Page:

University of Manchester. "Purified fish oils could help treat rare disease affecting newborn babies." ScienceDaily. ScienceDaily, 13 March 2014. <www.sciencedaily.com/releases/2014/03/140313092708.htm>.
University of Manchester. (2014, March 13). Purified fish oils could help treat rare disease affecting newborn babies. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2014/03/140313092708.htm
University of Manchester. "Purified fish oils could help treat rare disease affecting newborn babies." ScienceDaily. www.sciencedaily.com/releases/2014/03/140313092708.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins