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Plasma tool for destroying cancer cells

Date:
March 25, 2014
Source:
Springer Science+Business Media
Summary:
Plasma medicine is a new and rapidly developing area of medical technology. Specifically, understanding the interaction of so-called atmospheric pressure plasma jets with biological tissues could help in medical practice. Researchers have conducted a study of the different types of DNA damage induced by atmospheric pressure plasma exposure. This approach, they hope, could ultimately lead to devising alternative tools for cancer therapy as well as applications in hospital hygiene, dental care, skin diseases, antifungal care, chronic wounds and cosmetics treatments.

Plasma medicine is a new and rapidly developing area of medical technology. Specifically, understanding the interaction of so-called atmospheric pressure plasma jets with biological tissues could help to use them in medical practice.

Under the supervision of Sylwia Ptasinska from the University of Notre Dame, in Indiana, USA, Xu Han and colleagues conducted a quantitative and qualitative study of the different types of DNA damage induced by atmospheric pressure plasma exposure, the paper is published inThe European Physical Journal D, as part of a special issue on nanoscale insights into Ion Beam Cancer Therapy. This approach, they hope, could ultimately lead to devising alternative tools for cancer therapy as well as applications in hospital hygiene, dental care, skin diseases, antifungal care, chronic wounds and cosmetics treatments.

To investigate the DNA damage from the so-called non-thermal Atmospheric Pressure Plasma Jet (APPJ), the team adopted a common technique used in biochemistry, called agarose gel electrophoresis. They studied the nature and level of DNA damage by plasma species, so-called reactive radicals, under two different conditions of the helium plasma source with different parameters of electric pulses.

They also identified the effect of water on DNA damage. To do so, they examined the role of reactive radicals involved in DNA damage processes occurring in an aqueous environment. They then compared them to previous results obtained in dry DNA samples.

The next step would involve investigating plasma made from helium mixtures with different molecular ratios of other gases, such as oxygen, nitrous oxide, carbon dioxide and steam, under different plasma source conditions. The addition of another gas is expected to increase the level of radical species, such as reactive oxygen species and reactive nitrogen species, known to produce severe DNA damage. These could, ultimately, help to destroy cancerous tumour cells.


Story Source:

The above story is based on materials provided by Springer Science+Business Media. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xu Han, William A. Cantrell, Erika E. Escobar, Sylwia Ptasinska. Plasmid DNA damage induced by helium atmospheric pressure plasma jet. The European Physical Journal D, 2014; 68 (3) DOI: 10.1140/epjd/e2014-40753-y

Cite This Page:

Springer Science+Business Media. "Plasma tool for destroying cancer cells." ScienceDaily. ScienceDaily, 25 March 2014. <www.sciencedaily.com/releases/2014/03/140325094818.htm>.
Springer Science+Business Media. (2014, March 25). Plasma tool for destroying cancer cells. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2014/03/140325094818.htm
Springer Science+Business Media. "Plasma tool for destroying cancer cells." ScienceDaily. www.sciencedaily.com/releases/2014/03/140325094818.htm (accessed July 23, 2014).

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