Featured Research

from universities, journals, and other organizations

Role of magnetic nanoparticles in breast cancer treatment

Date:
April 7, 2014
Source:
Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center
Summary:
While exploring the promise of magnetic nanoparticle (mNP) hyperthermia in breast cancer treatment, a researcher reviews preclinical studies and discusses plans for early-phase clinical studies in humans. This evolving treatment approach involves the injection of nanoparticles into the tumor, which are then activated with magnetic energy. Once activated the nanoparticles produce heat inside the cancer cell. The heat kills the cancer cell with minimal damage to surrounding tissue.

Shown here at 9900x magnification, tumor cells readily take up magnetic nanoparticles (black objects). When a tumor containing nanoparticles is exposed to an alternating magnetic field, the nanoparticles will heat and kill the tumor cells.
Credit: Image courtesy of Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center

In a presentation exploring the promise of magnetic nanoparticle (mNP) hyperthermia in breast cancer treatment, Dartmouth researcher P. Jack Hoopes, DMV, PhD, reviewed preclinical studies conducted at Norris Cotton Cancer Center and discuss plans for early-phase clinical studies in humans at the annual meeting of the American Association for Cancer Research (AACR).

Related Articles


This evolving treatment approach involves the injection of nanoparticles into the tumor, which are then activated with magnetic energy. Once activated the nanoparticles produce heat inside the cancer cell. The heat kills the cancer cell with minimal damage to surrounding tissue.

P. Jack Hoopes, DVM, PhD, co-director of Norris Cotton Cancer Center's Nanotechnology Working Group, has led efforts in creating platforms, approaches, and equipment to test mNP in the laboratory and in the exam room at the Dartmouth Center of Nanotechnology Excellence.

Hoopes presented the enhanced uptake of breast cancer antibody tagged mNPs in xenograph breast tumors (human tumors grown in mice) following systemic delivery (intravenous). The antibodies resulted in a 2.5 fold increase in tumor mNPs. The antibodies used were similar to the commercially available breast cancer antibody Herceptin (trastuzumab). Researchers used only the cell binding (fab) fragment of the antibody. This antibody-fab fragment was produced in the Thayer School of Engineering at Dartmouth laboratory of protein engineers Tillman Gerngross and Karl Griswold.

"Although we initially used the mNP therapy in an intra-tumoral delivery manner, and it has been effective, our goal and much of our current research is systemic mNP administration aimed at invasive and metastatic cancer," said Hoopes. "This is where the antibodies come in and the highly specific MRI based NP imaging we are conducting at the Center for Magnetic Resonance Research, University of Minnesota with Professor Michael Garwood."

Hoopes' presentation reviewed biodistribution studies in mice, nanoparticle heating characterization in vitro and in vivo, efficacy studies in mouse tumor models and spontaneous canine oropharyngeal tumors, studies combining nanoparticle hyperthermia with ionizing radiation and chemotherapy and MRI-based nanoparticle imaging. He also addressed Dartmouth's preparation for clinical trials, including navigating the Institutional Review Board (IRB) and the Food and Drug Administration (FDA) and the services provided by the FDA/NIH's Nanoparticle Characterization Laboratory.


Story Source:

The above story is based on materials provided by Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. "Role of magnetic nanoparticles in breast cancer treatment." ScienceDaily. ScienceDaily, 7 April 2014. <www.sciencedaily.com/releases/2014/04/140407090226.htm>.
Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. (2014, April 7). Role of magnetic nanoparticles in breast cancer treatment. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2014/04/140407090226.htm
Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. "Role of magnetic nanoparticles in breast cancer treatment." ScienceDaily. www.sciencedaily.com/releases/2014/04/140407090226.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Newsy (Mar. 5, 2015) A survey of Boston mothers and toddlers found that 15 percent of two-year-olds drink coffee and 2.5 percent of 1-year-olds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins