Featured Research

from universities, journals, and other organizations

Hormone therapy linked to lower non-Hodgkin lymphoma risk

Date:
April 7, 2014
Source:
City of Hope
Summary:
Menopausal hormone therapy use is linked to a lower risk of B-cell non-Hodgkin lymphoma, research has found. "The connection between lymphomas and menopausal hormone therapy use hinges on understanding the disease's biology and the window of susceptibility," the lead researcher said. "Hormone therapy is of interest because the loss of estrogen coupled with aging in women result in decreased immune function, which can elevate risk of non-Hodgkin lymphoma."

Hormone therapy, which is prescribed to women for relief of menopausal symptoms such hot flashes, night sweats and vaginal dryness, has recently seen a decline in popularity (and use) due to its link to an increased risk of breast and endometrial cancer. But City of Hope researchers have found that menopausal hormone therapy may actually lower the risk of B-cell non-Hodgkin lymphoma.

Related Articles


Sophia Wang, Ph.D., associate professor at City of Hope's Division of Cancer Etiology and first author of this study, will present the findings at the American Association for Cancer Research (AACR) annual meeting on Monday, April 7.

"The connection between lymphomas and menopausal hormone therapy use hinges on understanding the disease's biology and the window of susceptibility," Wang said. "Hormone therapy is of interest because the loss of estrogen coupled with aging in women result in decreased immune function, which can elevate risk of non-Hodgkin lymphoma."

For this study, Wang and her colleagues examined data from the Los Angeles Cancer Surveillance Program, comparing 685 postmenopausal women diagnosed with B-cell non-Hodgkin lymphoma to 685 postmenopausal women who did not have the disease and assessing their use of menopausal hormone therapy (either estrogen alone or estrogen with progestin, in either pill, patch, topical cream or injected forms).

After controlling for factors including age, race and socioeconomic status, Wang's team found that women who reported using any form of menopausal hormone therapy were approximately 30 percent less likely to be diagnosed with B-cell non-Hodgkin lymphoma, compared to women who reported never using menopausal hormone therapy.

Additional analysis showed that the risk reduction was even greater for women who initiated menopausal hormone therapy at a young age (45 years old or less) and used it for at least five years. This group was approximately 40 percent less likely to be diagnosed with a B-cell non-Hodgkin lymphoma compared to those who had never used hormone therapy.

Wang said these findings supported one part of her hypothesis, but further research will be needed to determine the exact biological mechanisms that might be linked to a lower non-Hodgkin lymphoma risk. These mechanisms could include supporting a healthy immune system or reducing inflammation.

Wang cautioned that the findings are preliminary and should not change current recommendations and guidelines for menopausal hormone therapy use.

Due to well-established evidence tying menopausal hormone therapy to elevated risks of breast and endometrial cancers, the American Cancer Society recommends that women considering, or using, this therapy to do so at the lowest effective dose for the shortest amount of time needed and that they discuss with their physicians about other treatments to alleviate menopausal symptoms.


Story Source:

The above story is based on materials provided by City of Hope. The original article was written by H. Chung So. Note: Materials may be edited for content and length.


Cite This Page:

City of Hope. "Hormone therapy linked to lower non-Hodgkin lymphoma risk." ScienceDaily. ScienceDaily, 7 April 2014. <www.sciencedaily.com/releases/2014/04/140407164602.htm>.
City of Hope. (2014, April 7). Hormone therapy linked to lower non-Hodgkin lymphoma risk. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2014/04/140407164602.htm
City of Hope. "Hormone therapy linked to lower non-Hodgkin lymphoma risk." ScienceDaily. www.sciencedaily.com/releases/2014/04/140407164602.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins