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New form of treatment to reduce risk of surgery-related ischemic brain injury?

Date:
May 2, 2014
Source:
Helsingin yliopisto (University of Helsinki)
Summary:
Ischemic brain injury due to heart and vascular surgery causes more than 100,000 deaths annually in Europe and the United States. In addition, approximately 10–20% of patients undergoing heart and vascular surgery – at least 1.5 million people in Europe and the United States every year – suffer from ischemic brain injury as a side-effect of their surgery. Now researchers suggest that they may have come up with a new treatment to this problem.

Ischemic brain injury due to heart and vascular surgery cause more than 100,000 deaths annually in Europe and the United States. In addition, approximately 10-20% of patients undergoing heart and vascular surgery -- at least 1.5 million people in Europe and the United States every year -- suffer from ischemic brain injury as a side-effect of their surgery.

Researchers from the Institute of Biotechnology at the University of Helsinki, Finland, have found that water-only fasting or protein-free diet before stroke reduce the amount of damaged brain tissue in rats by nearly 40%.

Academy Research Fellow Jaan-Olle Andressoo notes that reducing brain damage caused by surgery, some of which results in what are known as "silent strokes," would be extremely important. A silent stroke, often left undiagnosed, may disrupt the brain's capacity to process information. Patients may experience cognitive difficulties after heart surgery, e.g. find that they can no longer complete everyday tasks as easily as before.

"Minimising brain damage is the main target of our research, and we are now seeking partners to enable us to test the pre-surgery diets on patient groups."

Academy Research Fellow Kaisa Hartikainen, a neurologist at the Behavioural Neurology Research Unit at the Tampere University Hospital, considers the findings interesting.

"Despite an enormous amount of research in recent years into treatments and drugs that could protect neurons from irreversible damage caused by oxygen deprivation, neuroprotective treatments have largely proved ineffective in stroke patients. Results from short-term dietary restriction studies on rats, however, offer a promising new alternative for use in conjunction with surgical treatments associated with a significant risk for stroke.


Story Source:

The above story is based on materials provided by Helsingin yliopisto (University of Helsinki). Note: Materials may be edited for content and length.


Journal Reference:

  1. Kärt Varendi, Mikko Airavaara, Jenni Anttila, Sarah Vose, Anu Planken, Mart Saarma, James R. Mitchell, Jaan-Olle Andressoo. Short-term Preoperative Dietary Restriction Is Neuroprotective in a Rat Focal Stroke Model. PLoS ONE, 2014; 9 (4): e93911 DOI: 10.1371/journal.pone.0093911

Cite This Page:

Helsingin yliopisto (University of Helsinki). "New form of treatment to reduce risk of surgery-related ischemic brain injury?." ScienceDaily. ScienceDaily, 2 May 2014. <www.sciencedaily.com/releases/2014/05/140502081337.htm>.
Helsingin yliopisto (University of Helsinki). (2014, May 2). New form of treatment to reduce risk of surgery-related ischemic brain injury?. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2014/05/140502081337.htm
Helsingin yliopisto (University of Helsinki). "New form of treatment to reduce risk of surgery-related ischemic brain injury?." ScienceDaily. www.sciencedaily.com/releases/2014/05/140502081337.htm (accessed October 22, 2014).

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