Featured Research

from universities, journals, and other organizations

Triple negative breast cancer more likely to be diagnosed in black women, regardless of socioeconomic status

Date:
May 12, 2014
Source:
American Cancer Society
Summary:
An analysis of a large nationwide dataset finds that regardless of their socioeconomic status, black women were nearly twice as likely as white women to be diagnosed with triple-negative breast cancer, a subtype that has a poorer prognosis. Triple-negative breast cancers are those whose cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces. Triple-negative breast cancers tend to grow and spread more quickly than most other types of breast cancer, and a lack of these receptors limits treatment options.

An analysis of a large nationwide dataset finds that regardless of their socioeconomic status, black women were nearly twice as likely as white women to be diagnosed with triple-negative (TN) breast cancer, a subtype that has a poorer prognosis. The analysis also found that Asian/Pacific Islander women were more likely to be diagnosed with another subtype of breast cancer: so-called human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer. The study appears early online in Breast Cancer Research and Treatment.

Triple-negative breast cancers are those whose cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces. Triple-negative breast cancers tend to grow and spread more quickly than most other types of breast cancer, and a lack of these receptors limits treatment options.

Previous studies have indicated that non-Hispanic blacks and Hispanics were more likely to be diagnosed with triple negative breast cancer than non-Hispanic whites. Some studies have suggested that the higher odds of breast cancer subtypes with unfavorable prognoses in minority racial/ethnic groups could be explained by differences in socioeconomic status. However, these studies were limited by their small and incomplete sampling.

For the current study, scientists led by Helmneh Sineshaw, M.D., MPH, analyzed data from 260,174 breast cancer cases recorded in the National Cancer Data Base (NCDB), a national hospital-based cancer registry database jointly sponsored by the American College of Surgeons and the American Cancer Society. The analysis showed that patients with low socioeconomic status had higher proportions of triple negative breast cancers than did patients with high or moderate socioeconomic status. However, even after controlling for socioeconomic status, the difference remained: black women were 1.84 times as likely to be diagnosed with the triple negative subtype. The researchers also found that compared with white women, Asian/Pacific Islander women had higher odds of presenting with HER2-overexpressing breast cancer, a difference that was also observed at every level of socioeconomic status.

"The excess odds of triple negative breast cancer in blacks compared to whites were remarkably similar, about 80% higher, in each socioeconomic group," said Dr. Sineshaw. "That consistent increase suggests factors other than differences in socioeconomic status play a strong role in the excess odds seen in black women. Further studies are needed to identify those factors."


Story Source:

The above story is based on materials provided by American Cancer Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Helmneh M. Sineshaw, Mia Gaudet, Elizabeth M. Ward, W. Dana Flanders, Carol Desantis, Chun Chieh Lin, Ahmedin Jemal. Association of race/ethnicity, socioeconomic status, and breast cancer subtypes in the National Cancer Data Base (2010–2011). Breast Cancer Research and Treatment, 2014; DOI: 10.1007/s10549-014-2976-9

Cite This Page:

American Cancer Society. "Triple negative breast cancer more likely to be diagnosed in black women, regardless of socioeconomic status." ScienceDaily. ScienceDaily, 12 May 2014. <www.sciencedaily.com/releases/2014/05/140512112553.htm>.
American Cancer Society. (2014, May 12). Triple negative breast cancer more likely to be diagnosed in black women, regardless of socioeconomic status. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/05/140512112553.htm
American Cancer Society. "Triple negative breast cancer more likely to be diagnosed in black women, regardless of socioeconomic status." ScienceDaily. www.sciencedaily.com/releases/2014/05/140512112553.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins